MRI May Predict Stroke and Heart Attack Risk in Diabetic Patients

Whole-body magnetic resonance imaging MRI may serve as an effective noninvasive application for assessing the risk of heart attack and stroke in diabetic patients, according to new research.

These new findings were published online September 2013 in the journal Radiology. Diabetes is a metabolic disease characterized by an increased concentration of glucose in the blood. There are 347 million diabetic patients worldwide, and the World Health Organization (WHO; Geneva, Switzerland) projects that diabetes will be the seventh leading cause of death by 2030.

Diabetic patients are known to develop atherosclerosis (thickening of the arterial walls) at an accelerated rate, resulting in a higher incidence of major adverse cardiac and cerebrovascular events (MACCEs), such as a heart attack or stroke. However, there are wide variations in the degree of risk for adverse events among diabetic patients.

Recently, whole-body MRI has emerged as a promising means to assess the cardiovascular systems of people with diabetes. “One of the major advantages of whole-body MRI in this population is that the technique itself is not associated with radiation exposure, and larger body areas can be covered without increased risk, especially in younger patients,” said Fabian Bamberg, MD, MPH, from the department of radiology at Ludwig-Maximilians University (Munich, Germany). “As such, MRI can be used to evaluate the whole-body degree of disease burden that is not clinically apparent yet.”

Dr. Bamberg and colleagues studied the predictive value of whole-body MRI for the occurrence of MACCE in 65 patients with diabetes. The patients underwent a contrast-enhanced whole-body MRI protocol, including brain, cardiac and vascular sequences. The researchers then conducted follow-up inquiries to assess the rate of MACCE in the study group.

Follow-up information was available for 61 patients. After a median of 5.8 years, 14 patients had experienced MACCE. Patients who had detectable vascular alterations on whole-body MRI faced a cumulative MACCE risk rate of 20% at three years, and 35% at six years. None of the patients with a normal whole-body MRI went on to experience MACCE.

The findings point to a role for whole-body MRI as an accurate prognostic tool for diabetic patients that could speed up effective treatments to those at risk, according to Dr. Bamberg. “Whole-body MRI may help in identifying patients who are at very high risk for future events and require intensified treatment or observation,” he said. “Conversely, the absence of any changes on whole-body MRI may reassure diabetic patients that their risk for a heart attack, stroke, or other major cardiac or cerebrovascular event is low.”

Beside with its prognostic accuracy, whole-body MRI has other advantages over existing methods of determining heart attack risk, according to Dr. Bamberg. “Other established and valuable tools, such as myocardial perfusion imaging or computed tomography [CT] for quantification of coronary calcification, are generally limited to cardiac evaluation due to their associated risk profiles,” he said. “Also, MRI provides unique insights into soft tissue pathology, including cerebral and vascular changes, such as restriction of blood flow to the brain.”

Dr. Bamberg reported that while whole-body MRI is a comparatively recent advance that needs more research, the findings so far are promising. “Our study provides preliminary evidence that the technique may be beneficial for risk stratification in patients with diabetes,” he said. “We anticipate that emerging study findings in different diabetic cohorts will provide additional scientific basis to establish whole-body MRI as a screening modality.”

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