Collaboration on Use of High-Intensity Focused Ultrasound in Cancer Drug Delivery Yields Promising Results

Feasibility studies have successfully been completed aimed on improving delivery of cancer drugs using a combination of ultrasound sensitive liposomes and high-intensity focused ultrasound (HIFU).

This three-year Eureka label research cooperation program between Epitarget, AS (Oslo, Norway), academic laboratory INSERM (Institut National de la Santé et de la Recherche Médicale; Paris, France), and EDAP TMS, AS (Lyon, France) confirmed that HIFU activates the encapsulated cancer drug doxorubicin after accumulation in solid tumors and thereby facilitates drug delivery. The parties plan to initiate a preclinical study to confirm safety and efficacy of the innovative approach.

Research and development director, Emmanuel Blanc, said, "The completion of this feasibility study marks a preclinical milestone as it further demonstrates EDAP's ability to adapt its HIFU technology to new therapeutic applications. Between our extensive experience in focused ultrasound development and INSERM's expertise in HIFU, we are very well positioned to utilize our innovative HIFU technology for such targeted therapeutic approaches.

Esben A. Nilssen, Ph.D., Epitarget's chief executive officer, said, "Our team is very excited that the demonstration of Epitarget's ultrasound sensitive liposomes in combination with therapeutic ultrasound enhanced the efficacy of established cancer drugs. It provides hope to millions of cancer patients, illustrates the innovative force of cross-functional teams, and fills Epitarget with energy and determination to continue the leading role in this innovative program.”

Marc Oczachowski, EDAP's chief executive officer, continued, "Therapeutic ultrasound is gradually gaining ground in cancer treatment approach. We clearly see a growing interest in minimally invasive focal therapies for cancer tumors. Our 20 years expertise in the treatment of localized prostate cancer using HIFU has long been demonstrated and we are excited to further participate in the development of such new projects aiming at improving cancer drug delivery. While we expand our expertise in HIFU to further applications, we remain fully focused on developing our HIFU technology and adapt it to the current focal therapy trend to treat prostate cancers. We believe that the focal therapy approach represents a unique opportunity for Ablatherm HIFU to become the gold standard of treatment for prostate cancer.”

Related Links:
Epitarget
INSERM
EDAP TMS