We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
GLOBETECH PUBLISHING LLC

Download Mobile App




Novel MRI Contrast Agent Swiftly Eliminated from Body

By MedImaging International staff writers
Posted on 12 Jan 2021
Print article
Image: MRI manganese-based contrast agents are as efficient as gadolinium, but less toxic (Photo courtesy of Eric Gale/ MGH)
Image: MRI manganese-based contrast agents are as efficient as gadolinium, but less toxic (Photo courtesy of Eric Gale/ MGH)
A new study suggests that a manganese (Mn) based magnetic resonance imaging (MRI) contrast agent could soon replace gadolinium-based contrast agents (GBCAs) as a non-toxic alternative.

Researchers at Massachusetts General Hospital (MGH; Boston, USA) and Harvard Medical School (HMS; Boston, MA, USA) conducted a study to compare the new contrast agent, Mn-PyC3A, to the older Mn-based contrast agent mangafodipir (Mn-DPDP), and to the GBCA gadoterate (Gd-DOTA). For the study, the researchers used simultaneous positron emission tomography (PET) and MRI (PET-MRI) to compare pharmacokinetics, in-vivo biodistribution, and whole-body elimination in a rat model.

The results revealed that while both Mn-PyC3A and Mn-DPDP are eliminated via mixed hepatobiliary and renal routes, a greater fraction of the Mn-PyC3A contrast agent was eliminated by renal filtration. Whole-body PET images showed that Mn-PyC3A was efficiently eliminated, whereas Mn-DPDP was retained throughout the body. The experimental data also showed significantly more efficient whole-body elimination of Mn-PyC3A than Gd-DOTA both one day and one week after injection. The study was published on October 30, 2020, in Investigative Radiology.

“This manganese-based contrast agent does everything a GBCA would do; this is obviously important for patients with chronic kidney disease and other forms of renal insufficiency that might require careful risk/benefit analysis before undergoing a GBCA-enhanced MRI,” said senior author biomedical engineer Eric Gale, PhD, of MGH and HMS, co-inventor of Mn-PyC3A. “But we can also envision giving Mn-PyC3A to any patient requiring a contrast-enhanced MRI. There are patients who require many GBCA-enhanced MRI examinations over the course of years for disease surveillance or screening.”

Efficient elimination of a contrast agent is critical for tissue health. Since Gadolinium is eliminated only from the kidneys, retention from GBCAs can cause nephrogenic systemic fibrosis, and it is also retained in the brain, bones, skin and other organs, even in patients with normal kidney function. Mn-PyC3A, on the other hand, is also eliminated from the liver, compensating for diminished renal function in kidney patients and ensuring a more rapid and complete elimination.

Related Links:
Massachusetts General Hospital
Harvard Medical School


Gold Member
Solid State Kv/Dose Multi-Sensor
AGMS-DM+
Laptop Ultrasound Scanner
PL-3018
New
Ultrasound Doppler System
Doppler BT-200
Mammography System
MAMMOVISTA B.smart

Print article

Channels

Ultrasound

view channel
Image: Structure of the proposed transparent ultrasound transducer and its optical transmittance (Photo courtesy of POSTECH)

Ultrasensitive Broadband Transparent Ultrasound Transducer Enhances Medical Diagnosis

The ultrasound-photoacoustic dual-modal imaging system combines molecular imaging contrast with ultrasound imaging. It can display molecular and structural details inside the body in real time without... Read more

Nuclear Medicine

view channel
Image: PET/CT of a 60-year-old male patient with clinical suspicion of lung cancer (Photo courtesy of EJNMMI Physics)

Early 30-Minute Dynamic FDG-PET Acquisition Could Halve Lung Scan Times

F-18 FDG-PET scans are a way to look inside the body using a special dye, and these scans can be either static or dynamic. Static scans happen 60 minutes after the dye is administered into the body, showing... Read more

Imaging IT

view channel
Image: The new Medical Imaging Suite makes healthcare imaging data more accessible, interoperable and useful (Photo courtesy of Google Cloud)

New Google Cloud Medical Imaging Suite Makes Imaging Healthcare Data More Accessible

Medical imaging is a critical tool used to diagnose patients, and there are billions of medical images scanned globally each year. Imaging data accounts for about 90% of all healthcare data1 and, until... Read more

Industry News

view channel
Image: The acquisition will expand IBA’s medical imaging quality assurance offering (Photo courtesy of Radcal)

IBA Acquires Radcal to Expand Medical Imaging Quality Assurance Offering

Ion Beam Applications S.A. (IBA, Louvain-La-Neuve, Belgium), the global leader in particle accelerator technology and a world-leading provider of dosimetry and quality assurance (QA) solutions, has entered... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.