Combined Imaging Technique Used in Breast Surgery

Clinicians injected F-18-FDG tracer 45-60 minutes before surgery and then intraoperatively imaged tumor specimens in an investigational CLI imaging system immediately following tumor excision, for 22 patients suffering from invasive-breast cancer.

The results showed that F-18-FDG CLI was a useful low-risk tool for the intraoperative assessment of tumor margins during breast-conserving surgery.

Professor at King's College, Arnie D. Purushotham, MD, said, "Currently, approximately 1 in 5 women who undergo breast-conserving surgery, also known as lumpectomy, require repeat surgery due to inadequate excision of the tumor during the initial surgical procedure. By accurately assessing tumor resection margins intraoperatively with CLI, surgeons may be able to completely clear the cancer with a single operation, thereby reducing the number of breast cancer patients requiring a second, or even third, surgical procedure. The feasibility of intraoperative CLI as shown in this study, in combination with the wide applicability of F-18-FDG across a range of solid cancers, provides a stepping stone for clinical evaluation of this technology in other solid cancer types that also experience incomplete tumor resection due to close or involved margins."

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