We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App




Events

ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

CT Radiomics Helps Classify Small Lung Nodules

By MedImaging International staff writers
Posted on 01 Feb 2021
Print article
Image:  CT radiomics can help classify lung nodule malignancy (Photo courtesy of Getty Images)
Image: CT radiomics can help classify lung nodule malignancy (Photo courtesy of Getty Images)
A machine-learning (ML) algorithm can be highly accurate for classifying very small lung nodules found in low-dose CT lung screening programs, according to a new study.

Researchers at the BC Cancer Research Center (BCCRC; Vancouver, Canada) trained a linear discriminant analysis (LDA) ML algorithm--using data from the Pan-Canadian Early Detection of Lung Cancer (PanCan) study--to characterize, analyze, and classify small lung nodules as malignant or benign by extracting approximately 170 texture and shape radiomic features, following semi-automated nodule segmentation on the images. They then compared the performance of the algorithm with that of the Prostate, Lung, Colorectal, and Ovarian (PLCO) m2012 malignancy risk score calculator on another dataset.

The study cohort consisted of 139 malignant nodules and 472 benign nodules that were approximately matched in size. The researchers applied size restrictions (based on Lung-RADS classification criteria) to remove any nodules from the dataset that would already be considered suspicious, which would include any nodule with solid components greater than 8 mm in diameter. The results showed the ML algorithm significantly outperformed the (PLCO) m2012 risk-prediction model, especially when demographic data were added to radiomics analysis. The study was presented at the AACR Virtual Special Conference on Artificial Intelligence, Diagnosis, and Imaging, held during January 2021.

“The best results were achieved in a subset of patients who were younger than 64, female, did not have emphysema, smoked fewer than 42 pack years, did not have a family history of lung cancer, and were not current smokers,” said senior author and study presenter Rohan Abraham, PhD. “Combined with clinician expertise and experience, this has the potential to enable earlier intervention and reduce the need for follow-up CT.”

Current lung nodule classification relies on nodule size, a factor that is of limited use for sub-centimeter nodules, or on volume doubling time, a variable that requires follow-up CT exams. As a result, very small lung nodules, with solid components of less than 8 mm in diameter (and therefore below the Lung-RADS 4A risk-stratification threshold), are very difficult to classify, and they are often given a "wait and see" management plan.

Related Links:
BC Cancer Research Center


Print article
CIRS
Radcal

Channels

Industry News

view channel
Illustration

Siemens Completes Acquisition of Varian to Create Integrated Portfolio of Imaging, Laboratory Diagnostics, AI and Cancer Treatment

Siemens Healthineers (Erlangen, Germany) has successfully completed the acquisition of Varian Medical Systems, Inc. (Palo Alto, CA, USA), thus strengthening its position as a holistic partner in healthcare.... Read more
Copyright © 2000-2021 Globetech Media. All rights reserved.