We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
GLOBETECH PUBLISHING LLC

Download Mobile App




FAPI PET/CT Improves Staging of Newly Diagnosed Breast Cancer

By MedImaging International staff writers
Posted on 08 Jul 2024
Print article
Image
Image

18F-FDG PET/CT is commonly employed for staging breast cancer but faces challenges such as false positives in inflammatory breast lesions and reduced sensitivity in certain breast cancer subtypes. Earlier small-scale retrospective studies have indicated that 68Ga-FAPI may surpass 18F-FDG PET/CT in detecting primary tumors and metastases in breast cancer patients due to its higher sensitivity. Now, a new comparative analysis between FAPI and 18F-FDG PET/CT for the systemic staging of newly diagnosed breast cancer has demonstrated that FAPI PET/CT offers more accurate staging. Notably, nearly 20% of patients had their clinical stage revised based on FAPI PET/CT findings, highlighting its potential benefits and efficacy in clinical settings.

The study by researchers at Peking Union Medical College Hospital (Beijing, China) included a total of 121 patients newly diagnosed with breast cancer. All participants underwent 18F-FDG imaging, and of these, 53 were also imaged using 68Ga-FAPI-04 PET/CT, while another 68 underwent A118F-FAPI-04 PET/CT. Lesions were considered positive if their uptake was higher than the surrounding tissue. The TNM clinical stage was assessed from both 18F-FDG and FAPI PET/CT images based on criteria from the American Joint Committee on Cancer Staging Manual. FAPI led to a restaging of 19.8% of patients when compared with stages determined by 18F-FDG PET/CT. The study also found that treatment plans were enhanced for six patients following the discovery of additional bone lesions and internal mammary lymph nodes. Notably, FAPI PET/CT identified a higher stage in 21.7% of patients initially classified as stage IIA by 18F-FDG PET/CT. Researchers suggest that patients with stage IIA breast cancer should consider undergoing systemic staging with FAPI PET/CT at the time of initial diagnosis.

“There is currently a lack of evidence on the efficacy of FAPI PET/CT, especially in large sample cohorts. Our study sought to add to the literature by assessing FAPI PET/CT for the systemic staging of newly diagnosed breast cancer compared with 18F-FDG PET/CT,” said Zhixin Hao, MD, a nuclear medicine physician at Peking Union Medical College Hospital. “This study is significant as it has the potential to advance personalized treatment strategies for breast cancer patients. FAPI PET/CT for the initial staging of breast cancer has the potential to reduce unnecessary treatments and improve patient outcomes.”

Related Links:
Peking Union Medical College Hospital

New
Gold Member
X-Ray QA Meter
T3 AD Pro
New
Imaging Table
CFPM201
Illuminator
Trimline Basic
NMUS & MSK Ultrasound
InVisus Pro

Print article
Radcal

Channels

MRI

view channel
Image: MRI-linac allows clinicians to see what’s going on in the brain for the first time (Photo courtesy of Sylvester Comprehensive Cancer Center)

MRI Provides Early Warning System for Glioblastoma Growth

A new study has demonstrated the potential of combining imaging with radiation to shape glioblastoma treatment in real time. The research is the first to quantify tumor changes in glioblastoma patients... Read more

Ultrasound

view channel
Image: Disease captured by the hand-held 3D photoacoustic scanner (Photo courtesy of Dr. Nam Huynh)

Medical Imaging Breakthrough to Revolutionize Cancer and Arthritis Diagnosis

Photoacoustic tomography (PAT) imaging uses laser-generated ultrasound waves to detect subtle changes in small veins and arteries, typically less than a millimeter in size and up to 15mm deep in human tissues.... Read more

Imaging IT

view channel
Image: The new Medical Imaging Suite makes healthcare imaging data more accessible, interoperable and useful (Photo courtesy of Google Cloud)

New Google Cloud Medical Imaging Suite Makes Imaging Healthcare Data More Accessible

Medical imaging is a critical tool used to diagnose patients, and there are billions of medical images scanned globally each year. Imaging data accounts for about 90% of all healthcare data1 and, until... Read more

Industry News

view channel
Image: Focused ultrasound therapy is poised to become an essential tool in every hospital, cancer care center and physician office (Photo courtesy of Arrayus)

Bracco Collaborates with Arrayus on Microbubble-Assisted Focused Ultrasound Therapy for Pancreatic Cancer

Pancreatic cancer remains one of the most difficult cancers to treat due to its dense tissue structure, which limits the effectiveness of traditional drug therapies. Bracco Imaging S.A. (Milan, Italy)... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.