We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Agfa Radiology

Download Mobile App




Events

ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

Combination Treatment Offers Better Option for Colon Cancer Patients

By MedImaging International staff writers
Posted on 05 Jan 2022
Print article
Image: TheraSphere microscopic glass beads containing yttrium-90 (Photo courtesy of Boston Scientific)
Image: TheraSphere microscopic glass beads containing yttrium-90 (Photo courtesy of Boston Scientific)
Targeted radioembolization (TARE) alongside chemotherapy improves progress-free survival for patients with colorectal liver metastases (CLM), according to a new study.

Researchers at Northwestern University (NU; Evanston, IL, USA), the University of California, Los Angeles (UCLA; USA), and other institutions conducted an international, multicenter, open-label phase III trial of 428 patients with CLM randomly assigned to receive second-line systemic chemotherapy (with or without transarterial Yttrium-90 TARE) on a 1:1 basis. The two primary end points were progression-free survival (PFS) and hepatic PFS (hPFS), assessed by blinded independent central review.

The results showed that the patients receiving a combination of chemotherapy and TARE had longer progression-free survival, but did not improve overall survival. Some subsets of patients had greater benefit from TARE than others; characteristics which could identify patients who could benefit from addition of TARE were the location of the original colon tumor, genetic make-up of the tumor, and the amount of tumor in the liver. Importantly, the addition of TARE did not impact ability to receive subsequent therapy. The study was published on December 10, 2021, in the Journal of Clinical Oncology.

“Most patients with CLM are poor candidates for resection surgery. The cancer is either distributed in a way that it can't be operated on safely, or the size of the lesions makes it impossible,” said lead author professor Mary Mulcahy, MD, of NU. “We know systemic chemotherapy will ultimately fail, so we're looking for non-surgical therapy that can address these patients. This new treatment could be a better option compared to chemotherapy alone.”

TARE involves glass microspheres, within which a radioactive isotope (yttrium-90) is embedded. As healthy liver tissue is mainly perfused by the portal vein, TARE can be selectively administered to the tumors. The microspheres lodge in the small vessels of the tumor (embolization), emitting localized radiation therapy to targeted segments, results in tissue necrosis. The yttrium-90, with a half-life of 3.85 days, decays to Zirconium-90.

Related Links:
Northwestern University
University of California, Los Angeles



Print article

Channels

General/Advanced Imaging

view channel
Image: 3D cardiac map created with the EnSite X EP mapping system with OT (Photo courtesy of Abbott)

New Mapping System Improves Heart Rhythm Management

Thanks to omnipolar technology (OT), a new cardiac mapping system provides 360-degree views of the heart, regardless of catheter orientation. The Abbott (Abbott Park, IL, USA) EnSite X EP with OT system... Read more

Imaging IT

view channel
Illustration

Global AI in Medical Diagnostics Market to Be Driven by Demand for Image Recognition in Radiology

The global artificial intelligence (AI) in medical diagnostics market is expanding with early disease detection being one of its key applications and image recognition becoming a compelling consumer proposition... Read more

Industry News

view channel
Illustration

Global Breast Imaging Systems Market to Reach USD 1.3 Billion by 2024 Due to COVID-19-Led Patient Backlog

The global breast imaging market is expected to be driven by rising incidences of breast cancer, coupled with the huge backlog of women requiring breast cancer screening appointments due to COVID-19.... Read more
Copyright © 2000-2022 Globetech Media. All rights reserved.