We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Varian Medical Systems

Provides solutions for advancing cancer treatment, radiosurgery, X-ray imaging, & security, radiotherapy, radiosurger... read more Featured Products: More products

Download Mobile App


ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

Flash Proton Therapy Reduces Toxicity in Healthy Tissues

By MedImaging International staff writers
Posted on 23 Apr 2019
Print article
A non-invasive therapy for cancer that delivers high doses of radiation at ultra-high-speeds could represent a major breakthrough in the treatment of cancer.

Researchers at Varian Medical Systems (Varian, Palo Alto, CA, USA), the University of Maryland, and Maryland Proton Treatment Center divided study mice into groups who were sham-irradiated or exposed to a single-dose of 15, 17.5, and 20 Gy at conventional (1Gy/sec) or Flash (40 Gy/sec) proton radiation therapy (RT) speeds through whole thorax irradiation. The mice were sampled at 8, 16, 24, and 34 weeks post-irradiation for evaluation of complications and histopathological analysis of lung fibrosis.

The researchers observed up to a 30% reduction in lung fibrosis in the Flash-treated mice, as well as a 35% reduced incidence of skin dermatitis and improved overall survival. An evaluation of the molecular mechanism underlying the Flash effect was also performed through genome wide microarray analysis, which revealed that the major pathways differentially regulated between the two treatments regarding activation of DNA damage and repair, inflammation, and immune modulation. The study was presented at the American Association for Cancer Research (AACR) annual meeting, held during March-April 2019 in Atlanta (GA, USA).

“Strategies that would reduce normal tissue toxicity while maintaining potent tumor cell killing would enhance the therapeutic ratio and make radiotherapy more effective,” said Professor William Regine, MD, executive director of the Maryland Proton Treatment Center. “Partnering with Varian’s Global Translational Science team on the first proton Flash pre-clinical study is a significant step in building a foundation of research and bridging the gap to patient benefits in this potentially game-changing therapy.”

Proton therapy is a precise form of RT that uses charged particles instead of x-rays. It can be a more effective form of treatment than conventional radiotherapy as it is more precise, with minimal damage to surrounding tissue. Evidence is growing that protons can be effective in treating a number of cancers, in particular children and young people with brain tumors, for whom it appears to produce fewer side effects such as secondary cancers, growth deformity, hearing loss, and learning difficulties.

Gold Supplier
SBRT Phantom with Removable Spine
E2E SBRT Phantom with Removable Spine Model 036S-CVXX-xx
Ceiling-Mounted Digital X-Ray System
DigitalDiagnost C50
DR Retrofit Kit
Portable Color Doppler Ultrasound System

Print article



view channel
Image: MRI scan showing the fetus and placental compartments (Photo courtesy of WUSTL)

New MRI Method Automatically Detects Placental Health during Pregnancy

Early monitoring of the placenta can improve detection and prevention of pregnancy complications, such as preterm birth, fetal growth disorders and preeclampsia. Currently, standard MRI analysis methods... Read more


view channel
Image: The new Clarius MSK AI model speeds up diagnosis and treatment of musculoskeletal injuries (Photo courtesy of Clarius)

Handheld MSK Ultrasound Scanner Uses AI to Automatically Identify and Measure Tendons in Foot, Ankle and Knee

An artificial intelligence (AI) application for musculoskeletal (MSK) imaging that works with handheld point-of-care ultrasound devices automatically identifies, highlights, and measures tendon structures... Read more

General/Advanced Imaging

view channel
Image: CZT gamma detector for SPECT imaging (Photo courtesy of Kromek)

Low-Dose Molecular Breast Imaging (MBI) Could Improve Cancer Detection in Dense Breast Tissue

Traditional mammography is often less able to clearly image tumors due to the density of the breast tissue. Molecular breast imaging (MBI) technology uses a radioactive tracer that ‘lights up’ areas of... Read more

Imaging IT

view channel
Image: The new Medical Imaging Suite makes healthcare imaging data more accessible, interoperable and useful (Photo courtesy of Google Cloud)

New Google Cloud Medical Imaging Suite Makes Imaging Healthcare Data More Accessible

Medical imaging is a critical tool used to diagnose patients, and there are billions of medical images scanned globally each year. Imaging data accounts for about 90% of all healthcare data1 and, until... Read more
Copyright © 2000-2023 Globetech Media. All rights reserved.