We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
GLOBETECH PUBLISHING LLC

Download Mobile App




Targeted Breast Cancer Radiotherapy Reduces Side Effects

By MedImaging International staff writers
Posted on 17 Aug 2017
Print article
Partial-breast radiotherapy (RT) restricted to the vicinity of the original tumor results in fewer late normal-tissue adverse effects, claims a new study.

Researchers at the University of Cambridge (United Kingdom), The Institute of Cancer Research (ICR; London, United Kingdom), and other institutions conducted a multicenter, randomized, phase 3 trial in 30 RT centers across the UK involving 2,016 women aged 50 or older who underwent breast-conserving surgery for unifocal invasive ductal adenocarcinoma, with a tumor size of three cm or less, none to three positive axillary nodes, and minimum microscopic margins of non-cancerous tissue of two mm or more.

The patients were randomized to a reduced-dose RT group (673 patients), a partial-breast RT group (669 patients), and a whole-breast RT control group (674 patients). Field-in-field (FIF) intensity-modulated RT was delivered using standard tangential beams that were simply reduced in length for the partial-breast group. The primary endpoint was ipsilateral local relapse at five years for each experimental group. The results showed that 5-year absolute differences in local relapse (compared with the control group) were −0·73% for the reduced-dose and −0·38% for the partial-breast groups.

According to the researchers, the results indicate that non-inferiority can be claimed for both reduced-dose and partial-breast RT. Photographic evaluation and patient and clinical assessments recorded similar adverse effects following reduced-dose or partial-breast RT, including two patient domains--change in breast appearance and breast harder or firmer--that achieved significantly lower adverse effects as compared with whole-breast RT. The study was published on August 1, 2017, in The Lancet.

“We started this trial because there was evidence that if someone’s cancer returns, it tends to do so close to the site of the original tumor, suggesting that some women receive unnecessary radiation to the whole breast,” said lead author Charlotte Coles, MD, reader in breast radiation oncology at Cambridge University. “Now we have evidence to support the use of less, but equally effective, radiotherapy for selected patients.”

“We’re delighted that the results of this trial have the potential to lead to a real change in the way selected breast cancer patients are treated,” said senior author Professor Judith Bliss, PhD, of the ICR. “The technique used here can be carried out on standard radiotherapy machines, so we anticipate that these results will lead to further uptake of this treatment at centers across the country and worldwide.”

Related Links:
University of Cambridge
Institute of Cancer Research
Gold Member
Solid State Kv/Dose Multi-Sensor
AGMS-DM+
New
Breast Imaging Workstation
SecurView
Dose Area Product Meter
VacuDAP
New
Self-Driving Mobile C-arm
CIARTIC Move

Print article

Channels

Radiography

view channel
:	Image: The AI model could be a valuable adjunct to human radiologists in breast cancer diagnoses and risk prediction (Photo courtesy of 123RF)

AI Model Predicts 5-Year Breast Cancer Risk from Mammograms

Approximately 13% of U.S. women, or one in every eight, are predicted to develop invasive breast cancer over their lifetime, with 1 in 39 women (3%) succumbing to the illness, according to the American... Read more

General/Advanced Imaging

view channel
Image: The CIARTIC Move self-driving mobile C-arm has received FDA clearance (Photo courtesy of Siemens)

Self-Driving Mobile C-Arm Reduces Imaging Time during Surgery

Intraoperative imaging faces significant challenges due to staff shortages and the high demands placed on surgical teams in the operating room (OR). A common challenge during many OR procedures is the... Read more

Imaging IT

view channel
Image: The new Medical Imaging Suite makes healthcare imaging data more accessible, interoperable and useful (Photo courtesy of Google Cloud)

New Google Cloud Medical Imaging Suite Makes Imaging Healthcare Data More Accessible

Medical imaging is a critical tool used to diagnose patients, and there are billions of medical images scanned globally each year. Imaging data accounts for about 90% of all healthcare data1 and, until... Read more

Industry News

view channel
Image: Samsung Medison CEO Mr. Yongkwan Kim and Bracco Imaging CEO Dr. Fulvio Renoldi Bracco endorsed a MoU agreement (Photo courtesy of Bracco Group)

Samsung and Bracco Enter Into New Diagnostic Ultrasound Technology Agreement

Samsung Medison (Seoul, South Korea) and Bracco Imaging (Milan, Italy) have entered into a Memorandum of Understanding (MoU) agreement to pioneer a new area for diagnostic ultrasound devices and contrast agents.... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.