In Vivo Multispectral Imaging System Designed to Monitor Changes in Molecular Activity

A new in vivo multispectral imaging system is designed to enable researchers to precisely locate and monitor changes in molecular activity of specific areas of interest--long before morphologic changes can be detected--accelerating the development of effective therapeutics for disease treatment.

Investigators from the University of Notre Dame (South Bend, IN, USA) are using the latest in vivo and in vitro optical molecular imaging technology from Carestream Health (Rochester, NY,USA) Molecular Imaging as part of its cutting-edge research of infectious disease, bone disease, cancer, and other medical applications.

The In Vivo Imaging Core, part of the recently commissioned Notre Dame Integrated Imaging Facility (NDIIF), chose the Kodak in vivo multispectral imaging system FX for its multimodal molecular imaging needs. The imaging facility utilizes the system for a range of imaging techniques including chemiluminescent, fluorescent, X-ray, and radioisotopic applications.

"The Kodak multispectral system is very popular in our core imaging facility because it offers our researchers four powerful imaging modalities in a single system, and we use them all," said W. Matthew Leevy, Ph.D., research professor and managing director of the In Vivo Imaging Core, University of Notre Dame. "Of particular value is the multi-modal capability," he added. "The system's X-ray mode provides a convenient anatomical map with which to precisely coregister and accurately localize optical or radioisotopic signals emanating from target disease cells. This is an extremely powerful and useful combination."

Notre Dame's In Vivo Imaging Facility focuses on noninvasive methods to observe and image various disease models and biologic processes in living systems. It is colocated with the Freimann Life Science Center (FLSC), which provides a full range of veterinary services. Together, the NDIIF and FLSC provide animal care and imaging services to a wide range of investigators at the University and regional levels.

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University of Notre Dame
Carestream Health