We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
GLOBETECH PUBLISHING LLC

Download Mobile App




Novel PET Tracer Enhances Lesion Detection in Medullary Thyroid Cancer

By MedImaging International staff writers
Posted on 22 Jan 2024
Print article
Image: A newly developed PET imaging agent is effective in identifying medullary thyroid cancer (Photo courtesy of 123RF)
Image: A newly developed PET imaging agent is effective in identifying medullary thyroid cancer (Photo courtesy of 123RF)

Medullary thyroid cancer (MTC) represents about 3% of all thyroid cancer cases and is notably rare. It arises from different cells compared to other thyroid cancers, necessitating distinct imaging and treatment approaches. The overexpression of the cholecystokinin-2 receptor (CCK-2R) on most MTC cells has led to the development of various compounds targeting this receptor. However, many of these compounds suffer from low metabolic stability, which hampers their effectiveness in radioligand therapy. Now, a newly developed PET imaging agent has shown promise in both preclinical and clinical studies for identifying MTC, suggesting its potential as a theranostic tool in clinical settings.

In a study conducted by researchers at Stanford University (Stanford, CA, USA), three compounds—DOTA-CCK-66, DOTA-CCK 66.2, and DOTA-MGS5—were each labeled with different isotopes: 64Cu, 67Ga, and 177Lu. The team evaluated the CCK-2R affinity of these radiolabeled compounds on MTC cells. All compounds displayed high affinity, but DOTA-CCK-66 was selected for further study due to its superior in vitro properties, leading to the exclusion of DOTA-CCK-66.2 from subsequent analyses.

Following this, the researchers carried out in vivo stability, biodistribution, imaging, and competition studies using mice with CCK-2R-expressing tumors. Based on its comprehensive in vitro and in vivo performance, 68Ga-DOTA-CCK-66 was chosen for a proof-of-concept PET/CT application. Subsequently, two MTC patients underwent 68Ga-DOTA-CCK-66 PET/CT scans. The scans revealed that the compound was well tolerated by the patients, exhibited favorable biodistribution, and demonstrated high activity accumulation in the tumors.

“Due to increased in vivo stability, our compound reveals favorable tumor uptake as well as an improved activity clearance from off-target tissues,” said Constantin Lapa, MD, director of nuclear medicine at University Hospital Augsburg. “This could result in enhanced lesion detection in PET imaging and additionally enable targeted MTC radioligand therapy.”

Related Links:
Stanford University

Gold Member
Solid State Kv/Dose Multi-Sensor
AGMS-DM+
New
Thyroid Shield
Standard Thyroid Shield
New
Portable Radiology System
DRAGON ELITE & CLASSIC
New
MRI System
uMR 588

Print article
Radcal

Channels

Radiography

view channel
Image: LumiGuide enables doctors to navigate through blood vessels using light instead of X-ray (Photo courtesy of Philips)

3D Human GPS Powered By Light Paves Way for Radiation-Free Minimally-Invasive Surgery

In vascular surgery, doctors frequently employ endovascular surgery techniques using tools such as guidewires and catheters, often accessing through arteries like the femoral artery. This method is known... Read more

MRI

view channel
Image: The VR visualization platform provides patients and surgeons with access to real-time 3D medical imaging (Photo courtesy of Avatar Medical)

VR Visualization Platform Creates 3D Patient Avatars from CT and MR Images in Real-Time

Surgeons and patients must currently rely on black and white medical images interpreted by radiologists. This limitation becomes more pronounced in complex surgeries, leading to issues such as patient... Read more

Ultrasound

view channel
Image: Intravascular ultrasound provides a more accurate and specific picture of the coronary arteries (Photo courtesy of 123RF)

Intravascular Imaging Significantly Improves Outcomes in Cardiovascular Stenting Procedures

Individuals with coronary artery disease, which involves plaque accumulation in the arteries leading to symptoms like chest pain, shortness of breath, and heart attacks, often undergo a non-surgical procedure... Read more

General/Advanced Imaging

view channel
Image: Routine chest CT holds untapped potential for revealing patients at risk for cardiovascular disease (Photo courtesy of Johns Hopkins)

Routine Chest CT Exams Can Identify Patients at Risk for Cardiovascular Disease

Coronary artery disease (CAD) is the primary cause of death globally. Adults without symptoms but at risk can be screened using EKG-gated coronary artery calcium (CAC) CT scans, which are crucial in assessing... Read more

Imaging IT

view channel
Image: The new Medical Imaging Suite makes healthcare imaging data more accessible, interoperable and useful (Photo courtesy of Google Cloud)

New Google Cloud Medical Imaging Suite Makes Imaging Healthcare Data More Accessible

Medical imaging is a critical tool used to diagnose patients, and there are billions of medical images scanned globally each year. Imaging data accounts for about 90% of all healthcare data1 and, until... Read more

Industry News

view channel
Image: The acquisition will expand IBA’s medical imaging quality assurance offering (Photo courtesy of Radcal)

IBA Acquires Radcal to Expand Medical Imaging Quality Assurance Offering

Ion Beam Applications S.A. (IBA, Louvain-La-Neuve, Belgium), the global leader in particle accelerator technology and a world-leading provider of dosimetry and quality assurance (QA) solutions, has entered... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.