We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
GLOBETECH PUBLISHING LLC

Download Mobile App




New MRI Tool Introduced for Cancer Diagnosis and Therapy

By MedImaging International staff writers
Posted on 05 Sep 2018
Print article
Image: Superparamagnetic ferritin compound targeting a tumor cell (Photo courtesy of NUST-MISiS).
Image: Superparamagnetic ferritin compound targeting a tumor cell (Photo courtesy of NUST-MISiS).
A superparamagnetic ferritin compound improves the accuracy of diagnosing malignant cells and provides additional opportunities for cancer treatment, claims a new study.

Researchers at Helmholtz Zentrum München (Munich, Germany), the Russian National University of Science and Technology (NUST-MISiS; Moscow, Russia), and other institutions have synthesized a novel magnetoferritin, consisting of an endogenous human protein (ferritin) and a magnetic nucleus, which has been optimized for cellular uptake and ensuing trafficking to lysosomes. It can thus serve as a hypoallergenic contrast agent for optoacoustic imaging, and allow for selective photoablation of cells overexpressing the ferritin receptors.

According to the researchers, the genetically controlled uptake of the biomagnetic nanoparticles also strongly enhances third‐harmonic generation, due to the change of the refractive index caused by the magnetite–protein interface of ferritins entrapped in lysosomes. Selective uptake of magnetoferritin also enables detection of receptor‐expressing cells by magnetic resonance imaging (MRI), as well as efficient magnetic cell sorting and manipulation. A substantial increase in the blocking temperature of lysosomally entrapped magnetoferritin was also observed, which could allow for specific ablation of genetically defined cell populations by magnetic hyperthermia. The study was published in the May 2018 issue of Advanced Functional Materials.

“Spreading with the blood flow, magnetoferritin will be captured by the targeted tumor cells; as has been shown in a large number of studies, these cells actively capture transferrin, the protein responsible for the transport of iron in the blood,” said study co-author Professor Ulf Wiedwald, PhD, of the NUST-MISiS biomedical nanomaterials laboratory. “The receptors are capable of capturing the magnetoferritin as well. Once they get into the lysosomes of targeted cells, the magnetoferritin will further enhance the contrast signal.”

Transferrins are iron-binding blood plasma glycoproteins that control the level of free iron in biological fluids. Although the iron bound to transferrin is less than 0.1% of total body iron, it forms the most vital iron pool with the highest rate of turnover (25 mg/d). Transferrin also plays a key role in areas where erythropoiesis and active cell division occur, delivering iron absorption centers in the duodenum and white blood cell macrophages to all tissues.

Related Links:
Helmholtz Zentrum München
Russian National University of Science and Technology

Gold Member
Solid State Kv/Dose Multi-Sensor
AGMS-DM+
New
Oncology Information System
RayCare
New
Ultrasound Doppler System
Doppler BT-200
Dose Area Product Meter
VacuDAP

Print article

Channels

Radiography

view channel
:	Image: The AI model could be a valuable adjunct to human radiologists in breast cancer diagnoses and risk prediction (Photo courtesy of 123RF)

AI Model Predicts 5-Year Breast Cancer Risk from Mammograms

Approximately 13% of U.S. women, or one in every eight, are predicted to develop invasive breast cancer over their lifetime, with 1 in 39 women (3%) succumbing to the illness, according to the American... Read more

Nuclear Medicine

view channel
Image: The AI system uses scintigraphy imaging for early diagnosis of cardiac amyloidosis (Photo courtesy of 123RF)

AI System Automatically and Reliably Detects Cardiac Amyloidosis Using Scintigraphy Imaging

Cardiac amyloidosis, a condition characterized by the buildup of abnormal protein deposits (amyloids) in the heart muscle, severely affects heart function and can lead to heart failure or death without... Read more

General/Advanced Imaging

view channel
Image: The CIARTIC Move self-driving mobile C-arm has received FDA clearance (Photo courtesy of Siemens)

Self-Driving Mobile C-Arm Reduces Imaging Time during Surgery

Intraoperative imaging faces significant challenges due to staff shortages and the high demands placed on surgical teams in the operating room (OR). A common challenge during many OR procedures is the... Read more

Imaging IT

view channel
Image: The new Medical Imaging Suite makes healthcare imaging data more accessible, interoperable and useful (Photo courtesy of Google Cloud)

New Google Cloud Medical Imaging Suite Makes Imaging Healthcare Data More Accessible

Medical imaging is a critical tool used to diagnose patients, and there are billions of medical images scanned globally each year. Imaging data accounts for about 90% of all healthcare data1 and, until... Read more

Industry News

view channel
Image: Samsung Medison CEO Mr. Yongkwan Kim and Bracco Imaging CEO Dr. Fulvio Renoldi Bracco endorsed a MoU agreement (Photo courtesy of Bracco Group)

Samsung and Bracco Enter Into New Diagnostic Ultrasound Technology Agreement

Samsung Medison (Seoul, South Korea) and Bracco Imaging (Milan, Italy) have entered into a Memorandum of Understanding (MoU) agreement to pioneer a new area for diagnostic ultrasound devices and contrast agents.... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.