MRI Technology Designed for Diagnosing Painful Back Disorder

A new imaging technique used to identify biomarkers could indicate which patients have a painful, degenerative back condition is under development.

An interdisciplinary research team in the Cedars-Sinai Biomedical Imaging Research Institute (Los Angeles, CA, USA) department of biomedical sciences, Regenerative Medicine Institute and department of surgery received a grant from the US National Institutes of Health (NIH; Bethesda, MD, USA) to develop the technology.

Biomarkers are specific body substances, such as body fluids or fluids that can indicate specific health conditions. When noninvasive imaging modalities, such as magnetic resonance imaging (MRI), can identify exactly where the biomarkers are, researchers may alleviate the need for painful and invasive diagnostic procedures, and in the future, provide targeted, stem cell-based therapies to patients with the condition.

More than 85% of people in the United States alone suffer from low back pain, much of which is caused by intervertebral disc degeneration. Disc degeneration is a progressive condition, resulting in chronic pain in the back and neck. For some patients, degeneration can occur long before pain sets in, presenting symptoms, while others are affected almost immediately.

As described April 2014 in an article in the journal Magnetic Resonance in Medicine, identifying the exact disc that is the source of pain by employing the most sophisticated imaging techniques may save patients from painful and invasive diagnostic procedures, such as procedures in which physicians inject a contrast agent or non-toxic dye into patients’ spinal discs.

“The goal of our institute is to develop and apply novel imaging techniques that translate to clinical significance,” said Debiao Li, PhD, director of the Biomedical Imaging Research Institute, corresponding author of the article and a co-principal investigator on the NIH grant. “This imaging technology may allow us to do just this. By mapping a patient’s lower spinal region, we can identify the discs causing discomfort, which allows physicians to then treat accordingly.”

In the study, investigators developed various imaging techniques using MRI scanning, which can identify specific biomarkers to potentially provide a noninvasive diagnostic approach to intervertebral disc degeneration. The application, which has been evaluated on patients and in the laboratory, enabled researchers to exactly target the origin of pain and monitor the progression of each patient’s condition.

With this imaging technique, investigators in the Regenerative Medicine Institute are trying to generate a stem cell-based therapeutic agent for patients suffering from the degenerative disorder. “Our research team is interested in the role of stem cells in this disease and how we can utilize these cells to regenerate the disc and turn it back into a functional tissue,” said Dan Gazit, PhD, co-principal investigator on the grant and director of the skeletal regeneration and stem cell therapy laboratory in the department of surgery, the skeletal program in the Regenerative Medicine Institute and the molecular- and micro-imaging core facility. “Using this novel imaging technique, we will be able to evaluate the effect of our future stem cell therapies on back pain.”

Hyun Bae, MD, medical director of orthopedic spine surgery and director of spine education, who is co-investigator of the study, said, “By understanding where the source of pain comes from, physicians can better utilize surgical and non-surgical treatments to help patients live a more normal lifestyle.”

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Cedars-Sinai Biomedical Imaging Research Institute