Growing Use of Preop MRI Scanning Found to Increase Rate of Invasive Breast Cancer Surgeries

Heavy use of magnetic resonance imaging (MRI) may be leading to needless breast removal in older women with breast cancer, according to new research.

The study’s findings were published online August 14, 2013, of Breast Cancer Research and Treatment. “These data are concerning because the long-term benefits associated with bilateral mastectomy for older women with breast cancer are unclear,” said the study’s lead author Cary Gross, MD, associate professor of internal medicine at Yale School of Medicine (New Haven, CT, USA) and director of the Cancer Outcomes, Public Policy, and Effectiveness Research [COPPER] Center at Yale Cancer Center. “Patient concern about recurrence and survival must be balanced with the increased risk for complications associated with more aggressive cancer surgery, particularly when there is no proven benefit of the more aggressive option.”

The researchers monitored the use of breast MRI scanning and surgical care of 72,461 female US Medicare beneficiaries age 67–94, who were diagnosed with breast cancer during the years 2000 to 2009.

The investigators discovered a substantial surge in the use of preoperative breast MRI over the study period from 1% in 2000-2001 to 25% in 2008-2009. The researchers also found that women who received an MRI were more likely to subsequently undergo more aggressive surgical treatment. In women who received mastectomy, 12.5% of those who had MRI received bilateral mastectomy, whereas only 4.1% of those who did not have MRI had bilateral mastectomy.

The study also revealed that women undergoing MRI were more likely to have a contralateral prophylactic mastectomy. Among women who underwent mastectomy, 6.9% of women who had an MRI underwent contralateral prophylactic mastectomy, compared to 1.8% in women who did not have an MRI scan.

“There has been no randomized controlled clinical trial demonstrating improved outcomes for women who undergo preoperative breast MRI at any age,” said Brigid Killelea, MD, assistant professor of surgery at Yale School of Medicine, and first author on the study. “Breast conserving therapy, when feasible, remains the preferred approach for women with early stage breast cancer.”

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