Improving the Prognosis and Treatment of Osteoarthritis with Quantitative MRI

This is the first report of changes of defined biomarkers of bone shape being predictive of OA progression and highlights their superior ability to measure early and subtle changes in OA progression compared to traditional radiographic measures. These findings were presented at the Osteoarthritis Research Society International (OARSI) World Congress, held in Philadelphia (PA, USA), April 2013.

The project, now into its second year, continues on an aggressive stride to investigate further quantitative and semiquantitative image evaluations of bone and cartilage changes in the knee joint by mid-2013. Furthermore, testing on 12 biochemical markers using serum and urine from the study cohort has begun to assess joint tissue metabolism. These biochemical markers can also provide a direct measure of drug effect and mechanism of action to help better refine customized treatments for OA.

The OA Biomarkers Project is being led by two scientists from OARSI, Dr. David Hunter at the University of Sydney and Dr. Virginia Byers Kraus at Duke University (Durham, NC, USA). The project is run under the direction of the Biomarkers Consortium, a public-private biomedical research partnership managed by the FNIH and combines expertise from the National Institutes of Health (NIH), the Food and Drug Administration (FDA), and pharmaceutical and biotech companies, academia, and disease-focused nonprofit organizations.

Related Links:
Biomarkers Consortium
Foundation for the US National Institutes of Health