Neuroimaging Study Provides Insights into Motor Execution in Autistic Children

In the first neuroimaging study to examine motor execution in children with autism, researchers have discovered important new clues into the neurologic basis of autism.

The study, published online in the journal Brain on April 23, 2009, compared the brain activity of children with high functioning autism and their typically developing peers while performing a simple motor task--tapping their fingers in sequence. The researchers found that children with autism relied more heavily on a region of the brain responsible for conscious, effortful movement, while their normally developing peers utilized an area of the brain important for automating motor tasks. Children with autism also showed less connectivity between different regions of the brain involved in coordinating and executing movement, supporting the hypothesis that a decreased ability of distant regions of the brain to communicate with each other forms the neurologic basis of autism.

Researchers used functional magnetic resonance imaging (fMRI) scans to examine the brain activity of 13 children with high functioning autism and 13 typically developing children while performing sequential finger tapping. The typically developing children had increased activity in the cerebellum, a region of the brain important for automating motor tasks, whereas children with autism had increased activity in the supplementary motor area (SMA), a region of the brain important for conscious movement. This suggests children with autism have to recruit and rely on more conscious, effortful motor planning because they are not able to rely on the cerebellum to automate tasks.

Researchers also examined the functional connectivity of the brain regions involved in motor planning and execution in order to compare the activity between different brain regions involved in the same task. The children with autism showed considerably decreased connectivity between the different brain regions involved in motor planning and execution. These findings add to increasing evidence that autism is related to abnormalities in structural and functional brain connectivity, which makes it difficult for distant regions of the brain to learn skills and coordinate activities.

"Tapping your fingers is a simple action, but it involves communication and coordination between several regions of the brain,” said Dr. Stewart H. Mostofsky, senior study author and a pediatric neurologist in the department of developmental cognitive neurology at the Kennedy Krieger Institute (Baltimore, MD, USA). "These results suggest that in children with autism, fairly close regions of the brains involved in motor tasks have difficulty coordinating activity. If decreased connectivity is at the heart of autism, it makes sense social and communication skills are greatly impaired, as they involve even more complex coordination between more distant areas of the brain.”

While autism is characterized by impaired communication and social skills, these abilities are difficult for scientists to measure and quantify. In contrast, the neurologic mechanisms behind motor skills are well understood, and motor tasks can be objectively observed and measured. Examining motor execution provides researchers a way to study the basic brain systems important for learning and guiding actions, which has important implications for all learned behavior, including complex communication and social skills. Researchers from the Kennedy Krieger Institute have been using the study of motor skills as an important window into the neurobiologic basis of autism.

"When we learn to interact with the world around us, we acquire many skills,” said Dr. Mostofsky. "Whether they are complex social skills or simple motor skills, they all begin with the brain responding to a stimulus and learning the appropriate response. In this way, studying motor skills provides important information about how the brain of a child with autism learns differently, and how autism affects the basic neural systems important for acquiring all skills, from tapping your toes in rhythm to recognizing emotions in the facial expressions of others.”

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Kennedy Krieger Institute