Diffusion Tensor MRI Technique Used to Track Development of Parkinson's Disease

While finding a biomarker for Parkinson's disease that would let physicians screen for or track its progression remains an elusive goal, a team of researchers has shown that a noninvasive brain scanning technique offers potential. The tool may also help further the development of new drugs or neuroprotective agents to treat or ward off Parkinson's disease.

The researchers findings were published online in the in March 2009 issue of the journal Neurology. Dr. David Vaillancourt, assistant professor of kinesiology at the University of Illinois at Chicago (UIC; USA), along with colleagues from UIC and Rush University (Chicago, IL, USA), utilized a type of magnetic resonance imaging (MRI) scan called diffusion tensor imaging on 28 study participants, half with early symptoms of Parkinson's and the other half without.

The investigators scanned an area of the brain called the substantia nigra, a cluster of neurons that produce the neurotransmitter dopamine. Parkinson's patients have been found to have about half the number of dopaminergic neurons in specific areas of the substantia nigra as those without the disease.

Determining loss of dopaminergic neurons using traditional methods such as metabolic PET scans is costly, invasive, and requires injection of radioactive tracer chemicals. But the method studied by Dr. Vaillancourt and his group is noninvasive, comparatively inexpensive, and does not use radioactive tracers. "We're suggesting it's possible to eventually diagnose Parkinson's disease noninvasively and objectively by examining the part of the brain thought to underlie the causes of the disease," said Dr. Vaillancourt. No tool currently available can do that, he noted.

The researchers say the technique may also help develop neuroprotective agents to treat Parkinson's disease. Dr. Vaillancourt noted that it is difficult to identify a neuroprotective agent using current measures because the results are skewed by any therapy used to treat symptoms. "When you have a symptomatic effect of the neuroprotective agent, you need a lot of patients from multiple centers to determine if the neuroprotective agent works," he said. "But if you have a disease marker not affected by a dopaminergic therapy, then you would be able to test neuroprotective agents among smaller groups."

Dr. Vaillancourt believes that this new technology would enable faster development of drugs to treat Parkinson's. He noted that while the technique his group studied works well as a trait biomarker, which allows for diagnosis, it has not yet been shown to measure the state of the disease's progression. Further studies are planned.

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