We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App

PET Imaging Can Predict Survival in Patients with Brain Tumors

By MedImaging International staff writers
Posted on 18 Aug 2023
Print article
Image: PET imaging can help clinicians predict survival outcomes for patients with brain tumors (Photo courtesy of Freepik)
Image: PET imaging can help clinicians predict survival outcomes for patients with brain tumors (Photo courtesy of Freepik)

Glioblastoma is the most commonly occurring malignant primary brain tumor in adults and mostly has a grim prognosis. One protein connected to glioblastoma is Translocator protein (TSPO), which is expressed in the tumor. While PET radiotracers have been developed to bind to TSPO and can shed light on the characteristics of the tumor, there has been a lack of studies that demonstrate the clinical benefit of this approach. Now, a new study has found that PET imaging can help predict survival outcomes for patients suffering from this type of brain tumor.

Researchers at LMU University Hospital (Munich, Germany) have found a correlation between TSPO-PET imaging and reduced survival in patients newly diagnosed with glioblastoma who are undergoing radiotherapy. Their investigation focused on the relationships between TSPO-PET imaging using the F-18 GE-180 radiotracer and survival outcomes in a group of 45 patients with histologically confirmed isocitrate dehydrogenase (IDH) wild-type glioblastoma. The results were revealing: the median progression-free survival was 8.1 months, and overall survival was 10.8 months. At the time of the last follow-up after treatment, nearly all the patients (95.6%) had shown tumor progression, and the vast majority (88.9%) had passed away.

The research found that the level of tumoral uptake of F-18 GE-180 on the PET imaging had a significant connection to overall survival. Specifically, a high maximum standard uptake value (SUVmax) was linked to a considerably shorter overall survival time—8.3 months as opposed to 17.8 months. When compared with those patients exhibiting low tumoral uptake on TSPO-PET, patients with SUVmax higher than 2.2 faced a substantially elevated risk of death. The multivariate analysis found the hazard ratio to be 2.2. Glioblastoma continues to have limited successful treatment options, creating an urgent need for exploring new targets for both diagnostics and therapy. This study, however, offers a glimmer of hope, indicating that TSPO-PET imaging during the course of radiotherapy might serve as a potent tool in assessing treatment response.

"TSPO-PET seems to add prognostic insights beyond established clinical parameters and might serve as an informative tool as clinicians make survival predictions," noted the researchers.

Related Links:
LMU University Hospital 

Gold Member
Solid State Kv/Dose Multi-Sensor
Ultrasound System
Acclarix AX9
Color Doppler Ultrasound System
DRE Crystal 4PX
Brachytherapy Planning System
Oncentra Brachy

Print article



view channel
Image: The study supports annual screening beginning at age 40 as the best way to diagnose cancer early (Photo courtesy of 123RF)

Annual Mammography Beginning At 40 Cuts Breast Cancer Mortality By 42%

Breast cancer remains a leading cause of cancer-related deaths among women in the United States. Although studies have shown that regular mammography screenings can cut breast cancer fatalities by 40%,... Read more


view channel
Image: Researchers have created a new MRI brain extraction tool for neonates (Photo courtesy of 123RF)

Deep Learning Algorithm Performs Automatic Segmentation of Neonatal Brains from MR Images

Magnetic Resonance Imaging (MRI) is a vital tool in medical diagnostics, particularly because of its high-resolution images and superior soft tissue contrast, which make it crucial for brain evaluations.... Read more


view channel
Mindray`s comprehensive range of ultrasound machines include the Resona I9 (photo courtesy of Mindray)

Non-Invasive Ultrasound Technique Helps Identify Life-Changing Complications after Neck Surgery

Nasopharyngoscopy is an intrusive diagnostic medical procedure that involves the examination of the internal structures of the nose and throat (nasopharynx) using an endoscope inserted through the patient’s nose.... Read more

Nuclear Medicine

view channel
Image: The PET imaging technique can noninvasively detect active inflammation before clinical symptoms arise (Photo courtesy of 123RF)

New PET Tracer Detects Inflammatory Arthritis Before Symptoms Appear

Rheumatoid arthritis, the most common form of inflammatory arthritis, affects 18 million people globally. It is a complex autoimmune disease marked by chronic inflammation, leading to cartilage and bone... Read more

Imaging IT

view channel
Image: The new Medical Imaging Suite makes healthcare imaging data more accessible, interoperable and useful (Photo courtesy of Google Cloud)

New Google Cloud Medical Imaging Suite Makes Imaging Healthcare Data More Accessible

Medical imaging is a critical tool used to diagnose patients, and there are billions of medical images scanned globally each year. Imaging data accounts for about 90% of all healthcare data1 and, until... Read more

Industry News

view channel
Image: The acquisition will expand IBA’s medical imaging quality assurance offering (Photo courtesy of Radcal)

IBA Acquires Radcal to Expand Medical Imaging Quality Assurance Offering

Ion Beam Applications S.A. (IBA, Louvain-La-Neuve, Belgium), the global leader in particle accelerator technology and a world-leading provider of dosimetry and quality assurance (QA) solutions, has entered... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.