We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App

PSMA PET Imaging Improves Accuracy of Predicting Prostate Cancer Recurrence

By MedImaging International staff writers
Posted on 26 Jul 2023
Print article
Image: PSMA PET image (Photo courtesy of UCLA)
Image: PSMA PET image (Photo courtesy of UCLA)

Evaluating the risk of prostate cancer recurrence following radical prostatectomy—a procedure involving the complete removal of the prostate gland to eliminate the cancer—is vital in clinical practice to determine the most suitable treatment for each patient. Existing tools such as the CAPRA (Cancer of the Prostate Risk Assessment) score, which utilizes PSA, MRI, and biopsy information, help characterize the disease before surgery. However, to fully comprehend the extent of the disease, information is needed from the analysis of tissue taken from the prostate and pelvic lymph nodes during surgery (CAPRA-Surgery score: CAPRA-S). Now, a novel molecular imaging tool could improve the accuracy of recurrence risk predictions in patients with intermediate to high-risk prostate cancer undergoing surgery.

Researchers at the University of California’s two nationally ranked medical centers, UCLA (Los Angeles, CA, USA) and UCSF (San Francisco, CA, USA) have developed the prostate-specific membrane antigen PET imaging, or PSMA PET tool that provides prognostic information prior to starting treatment and can predict if a patient will have a high risk of cancer recurrence post-surgery. In order to determine if PSMA PET could enhance risk stratification and add value to current pre-surgery tools for predicting cancer recurrence, the researchers evaluated 240 patients who underwent PSMA PET before surgery. Three independent readers, who were blinded to the patient details, interpreted each scan.

The researchers then used PSMA PET and CAPRA scores to assess the risk of a biochemical recurrence, which is the reappearance of specific indicators of prostate cancer in the blood (PSA: Prostate Specific Antigen). Such recurrence happens in 20-50% of patients within 10 years after surgery. An early biochemical recurrence—occurring within three years after surgery—is linked with a poor prognosis and increased cancer-specific mortality. The study revealed that the risk assessment obtained by combining the pre-surgical CAPRA score and PSMA-PET matched the one derived using the post-surgical CAPRA-S score, which relies on tissue obtained during surgery. This suggests that PSMA-PET could serve as a robust predictive biomarker when histological data from surgery are unavailable. Further prospective studies employing pre-surgical PSMA-PET staging and longer follow-up periods are needed to confirm these findings and examine the impact of PSMA-PET on other outcomes such as the occurrence of metastasis and overall survival.

“In patients with prostate cancer considered for surgery, PSMA PET can provide information on the risk of recurrence after surgery, before the surgery even happens,” said Dr. Loic Djaileb, a visiting associate professor at UCLA and the study’s first author. “The imaging tool improves personalized treatments by helping the urologist decide whether or not to perform surgery, and to guide the surgical plan and the follow-up management after surgery.”

Related Links:

Gold Supplier
Conductive Gel
Gold Supplier
128 Slice CT Scanner
Supria 128
Advanced Radiotherapy System
uRT-linac 306
X-Ray Flat Panel Detector

Print article
Sun Nuclear -    Mirion



view channel
Image: The AI model improves tumor removal accuracy during breast cancer surgery (Photo courtesy of UNC School of Medicine)

AI Model Analyzes Tumors Removed Surgically in Real-Time

During breast cancer surgery, the surgeon removes the tumor, also known as a specimen, along with a bit of the adjacent healthy tissue to ensure all cancerous cells are excised. This specimen is then X-rayed... Read more


view channel
Image: MRI screen-detected breast cancers have been found to be most often invasive cancers (Photo courtesy of 123RF)

MRI Screen-Detected Breast Cancers Are Mostly Invasive

Annual breast MRI screening is advised for patients with a lifetime breast cancer risk exceeding 20%. There exists robust data about the features of mammographic screen-detected breast cancers, although... Read more


view channel
Image: FloPatch is a revolutionary tool that facilitates real-time precision in IV fluid management in sepsis (Photo courtesy of Flosonics)

Wireless, Wearable Doppler Ultrasound Revolutionizes Precision Fluid Management in Sepsis Care

When a patient comes to the hospital with sepsis, administering intravenous (IV) fluids is usually the first course of action. However, too much IV fluid can do more harm than good, causing additional... Read more

Nuclear Medicine

view channel
Image: An AI model can evaluate brain tumors on PET (Photo courtesy of Freepik)

AI Model for PET Imaging Determines Patient Response to Brain Tumor Treatments

The assessment of changes in metabolic tumor volume (MTV) through PET scans using specific radiotracers like F-18 fluoroethyl tyrosine (FET) plays a vital role in evaluating the treatment response in patients... Read more

Imaging IT

view channel
Image: The new Medical Imaging Suite makes healthcare imaging data more accessible, interoperable and useful (Photo courtesy of Google Cloud)

New Google Cloud Medical Imaging Suite Makes Imaging Healthcare Data More Accessible

Medical imaging is a critical tool used to diagnose patients, and there are billions of medical images scanned globally each year. Imaging data accounts for about 90% of all healthcare data1 and, until... Read more
Copyright © 2000-2023 Globetech Media. All rights reserved.