Light-Sensitive Cameras used to Study Lymphatic System

With the support of the light-sensitive cameras, investigators can view a fluorescent dye as it works its way through the lymphatic system. The fluorescent light emission can be seen through the skin.

The University of Texas Health Science Center at Houston (UTHealth; USA) has reached an agreement with other institutions that will allow it to take the next step in commercially developing a novel medical imaging system that uses night vision technology to manage a common side effect of cancer treatment. Officials in the Office of Technology Management at UTHealth have consolidated all patents and patent applications to the radiation-free system developed by UTHealth research scientist Eva Sevick, Ph.D., and collaborators.

Currently being evaluated in U.S. Food and Drug Administration (FDA)-approved clinical trials, the imaging system is being used to learn more about the lymphatic system and its role in disease. The lymphatic system transports everything from immune cells to blood components while playing a key role in the immune system and maintaining fluid balance. Little is known about the lymphatic system, however, and accurate imaging remains an obstacle, according to Dr. Sevick, professor and chair of Molecular Medicine at UTHealth's Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases.

Cancer treatments, including associated surgeries, can damage or destroy the lymphatic system and lead to a condition called lymphedema, which is associated with limb swelling and tissue fibrosis. With light-sensitive cameras, UTHealth's Dr.Sevick and her colleagues can view the fluorescent dye as it works its way through the lymphatic system. The fluorescent light emission can be seen through the skin. "Use of this system may allow clinicians to diagnose damage to a patient's lymphatic system well before symptoms develop. As a result, doctors using this system may be able to more accurately determine when to place patients on a different therapeutic regimen in order to avoid some of the more extreme symptoms from lymphedema," Dr. Sevick said.

Lymphedema occurs in 0.6% of live births, according to the Lymphatic Research Foundation (LRF; Glen Cove, NY, USA); however, most acquire it as result of surgery, infection, or trauma that interferes with the lymphatic system. Approximately 30% of breast cancer survivors develop lymphedema, according to the LRF.

The 19 patents and patent applications covering the system were previously held by a total of four separate academic institutions: Baylor College of Medicine (Houston, TX, USA) , Purdue University (West Lafayette, IN, USA), Texas A&M University (Collage Station, USA) and UTHealth. UTHealth recently assumed management of the entire portfolio. Baylor College of Medicine and the Texas A&M University System signed an agreement with UTHealth to make the consolidation of the patent portfolio a reality and to make the entire portfolio available for commercial development.

"This agreement provides a great example of local academic institutions working together to bundle intellectual property around an important, innovative technology to make it more attractive to commercial investment. We look forward to working with a commercial partner to get this technology into the clinic," said Bruce D. Butler, Ph.D., vice president for research and technology at UTHealth.

The system involves micro-doses of fluorescent dyes and specially modified near-infrared cameras. With the aid of the light-sensitive cameras, Dr. Sevick and her colleagues can observe a fluorescent dye as it works its way through the lymphatic system, indicating valve behavior and flow dynamics. The fluorescent light emission can be seen through the skin by the camera.

In contrast to systems that use computed tomography (CT) scanners or positron emission tomography (PET) imagers, the cameras used in this system are comparatively inexpensive and easy to use, according to Dr. Sevick. Moreover, the contrast dyes used in this system are non-radioactive and can generate images at microdosing levels. The ability to administer microdoses dramatically reduces the potential for side effects to the patient from the dyes and facilitates approval of the technology through the regulatory process, she said.

Dr. Sevick's group is developing additional applications of this system for imaging of other diseases.

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