We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App




Events

ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

Sugar Could Replace Contrast Agents in Brain MRI Scans

By MedImaging International staff writers
Posted on 05 Jul 2017
Print article
Image: Visualization of brain cancer by conventional contrast agents (L) and using glucose MRI method (R) (Photo courtesy of DKFZ).
Image: Visualization of brain cancer by conventional contrast agents (L) and using glucose MRI method (R) (Photo courtesy of DKFZ).
A new study suggests that glucose metabolism activity identified using magnetic resonance imaging (MRI) could help identify solid tumors or very aggressively growing tumor areas.

Researchers at the German Cancer Research Center (DKFZ; Heidelberg, Germany), the Max-Planck-Institute for Biological Cybernetics (Tuebingen, Germany), and other institutions used an ultrahigh field 7 Tesla MRI scanner to detect intracerebral regions of increased glucose concentration. For the study, they examined nine patients with newly diagnosed glioblastoma and four healthy volunteers between October 2015 and July 2016.

T1ρ-weighted dynamic glucose-enhanced (DGE) MRI was performed with injection of 100 mL of 20% d-glucose via the cubital vein. Glucose enhancement, given by the relative signal intensity change, was then quantitatively investigated in brain gray matter versus white matter in the healthy volunteers, and in tumor tissue versus normal-appearing white matter of patients with glioblastoma. The median signal intensities of the assessed brain regions were then compared.

The results demonstrated that in healthy volunteers, the median signal intensity in basal ganglia gray matter was significantly increased compared with that in white matter tissue. But in the glioblastoma patients, the median signal intensity in the glucose-enhanced tumor region, as displayed on the T1ρ-weighted DGE images, was significantly higher than that in contralateral normal-appearing white matter, indicating the pathophysiologically increased glucose uptake that occurs in human brain cancer. The study was published on June 23, 2017, in Radiology.

“We do not know yet how the shares of measured glucose are distributed between vessels and extracellular spaces on the one hand, and the cell interior on the other,” said study co-author radiologist Heinz-Peter Schlemmer, MD, PhD, of the DKFZ division of radiology. “If we can confirm that substantial signal levels originate from glucose in the cell interior, this would be important additional information for tumor imaging and functional MRI. This could enhance therapy planning and monitoring.”

MRI contrast agents enhance signals in blood vessels and in spaces between cells, but do not reach the interior of the cell; by contrast, glucose is taken up and then broken down in the body cells, and tumor cells are particularly hungry for glucose in order to feed their high-energy needs. As glucose is found at much lower levels in the body, magnetization transfer effect is used to reinforce the glucose signal by transferring the signal from glucose protons to bodily water, which is measured in MRI. The amount of glucose needed corresponds to about five sugar cubes.

Related Links:
German Cancer Research Center
Max-Planck-Institute for Biological Cybernetics

Print article
CIRS -  MIRION
Radcal

Channels

Radiography

view channel
Image: The Definium 656 HD is the company’s most advanced fixed X-ray system yet (Photo courtesy of GE Healthcare)

Next-Gen X-Ray System Brings ‘Personal Assistant’ to Radiology Departments

X-ray imaging often provides the entry point to diagnostic imaging - accounting for 60% of all imaging studies conducted. As a result, X-ray technologists, radiologists and radiology administrators are... Read more

Ultrasound

view channel
Image: The new device can better measure blood flow and oxygenation in the placenta (Photo courtesy of University of Pennsylvania)

Novel Method Combines Optical Measurements with Ultrasound for Monitoring ‘Engine’ of Pregnancy

The placenta, considered as the “engine” of pregnancy, is an organ that plays a crucial role in delivering nutrients and oxygen to the fetus. Placental dysfunction can lead to complications such as fetal... Read more

General/Advanced Imaging

view channel
Image: Radiologists would prefer AI-based decision support during screening mammography interpretation (Photo courtesy of Pexels)

Most Radiologists Want to Adopt AI Tools into Clinical Practice, Finds Study

Artificial intelligence (AI) may improve cancer detection and risk prediction during mammography screening, but radiologists’ preferences regarding its characteristics and implementation are unknown.... Read more

Imaging IT

view channel
Illustration

Global AI in Medical Diagnostics Market to Be Driven by Demand for Image Recognition in Radiology

The global artificial intelligence (AI) in medical diagnostics market is expanding with early disease detection being one of its key applications and image recognition becoming a compelling consumer proposition... Read more
Copyright © 2000-2022 Globetech Media. All rights reserved.