We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App

Magnetic Particle Imaging Device Identifies Alzheimer's Risk before Symptoms Onset

By MedImaging International staff writers
Posted on 08 Sep 2023
Print article
Image: The magnetic particle imaging device is capable of producing images of the human brain (Photo courtesy of Mitsubishi Electric)
Image: The magnetic particle imaging device is capable of producing images of the human brain (Photo courtesy of Mitsubishi Electric)

The prevalence of dementia, particularly Alzheimer's disease, continues to rise globally. Medications targeting the accumulation of amyloid-β in the brain, a potential contributor to Alzheimer's, have shown promise in slowing disease progression. Early intervention during periods of low amyloid-β buildup in the brain can delay disease onset. Therefore, there exists a critical need for technology capable of measuring amyloid-β accumulation and distribution. Now, the world's first high-sensitivity imaging device designed to operate at low frequencies with a compact power supply could revolutionize pre-Alzheimer's diagnosis. This device can image magnetic particles that bind to amyloid-β, the causative agent of Alzheimer's, enabling quantitative assessment of amyloid-β accumulation and distribution. The goal is to enable imaging-based predictions of Alzheimer's risk before symptoms manifest in the patient.

A team of scientists at Mitsubishi Electric (Tokyo, Japan), Okayama University (Okayama, Japan) and Osaka University (Suita, Japan) have developed the world's first high-sensitivity imaging device that operates at frequencies of 1 kHz or less, significantly reducing the power supply unit's size. Higher-frequency alternating magnetic fields enhance signal detection sensitivity. Existing compact devices, suitable for small animal testing like mice, typically use frequencies of around 25 kHz. The main challenge in adapting this technology for human use was the bulky power supply unit required to drive a larger coil. The device employs an alternating magnetic field generated by a coil to induce magnetic signals from injected magnetic particles within the body, using these signals to generate a three-dimensional image.

Drawing on their extensive expertise in electromagnetic technology and optimizing coil configurations for generating alternating magnetic fields and signal detection, Mitsubishi Electric devised a method that minimizes unwanted signals (noise) that can interfere with magnetic signal detection. This has enabled the development of a magnetic particle imaging device capable of sensitively capturing magnetic particle images across an area equivalent to the human brain's size. Most importantly, its ability to operate at frequencies below 1 kHz is a pioneering achievement that dramatically reduces the size of the necessary power supply unit. This breakthrough represents a significant leap toward realizing imaging tests capable of assessing the risk of Alzheimer's development before symptoms emerge.

Related Links:
Mitsubishi Electric
Okayama University
Osaka University 

Gold Supplier
IMRT Thorax Phantom
CIRS Model 002LFC
Gold Supplier
128 Slice CT Scanner
Supria 128
Radiology Generator
S Series
Portable DR Flat Panel Detector

Print article
Sun Nuclear -    Mirion



view channel
Image: The AI model improves tumor removal accuracy during breast cancer surgery (Photo courtesy of UNC School of Medicine)

AI Model Analyzes Tumors Removed Surgically in Real-Time

During breast cancer surgery, the surgeon removes the tumor, also known as a specimen, along with a bit of the adjacent healthy tissue to ensure all cancerous cells are excised. This specimen is then X-rayed... Read more


view channel
Image: MRI screen-detected breast cancers have been found to be most often invasive cancers (Photo courtesy of 123RF)

MRI Screen-Detected Breast Cancers Are Mostly Invasive

Annual breast MRI screening is advised for patients with a lifetime breast cancer risk exceeding 20%. There exists robust data about the features of mammographic screen-detected breast cancers, although... Read more


view channel
Image: FloPatch is a revolutionary tool that facilitates real-time precision in IV fluid management in sepsis (Photo courtesy of Flosonics)

Wireless, Wearable Doppler Ultrasound Revolutionizes Precision Fluid Management in Sepsis Care

When a patient comes to the hospital with sepsis, administering intravenous (IV) fluids is usually the first course of action. However, too much IV fluid can do more harm than good, causing additional... Read more

Nuclear Medicine

view channel
Image: An AI model can evaluate brain tumors on PET (Photo courtesy of Freepik)

AI Model for PET Imaging Determines Patient Response to Brain Tumor Treatments

The assessment of changes in metabolic tumor volume (MTV) through PET scans using specific radiotracers like F-18 fluoroethyl tyrosine (FET) plays a vital role in evaluating the treatment response in patients... Read more

Imaging IT

view channel
Image: The new Medical Imaging Suite makes healthcare imaging data more accessible, interoperable and useful (Photo courtesy of Google Cloud)

New Google Cloud Medical Imaging Suite Makes Imaging Healthcare Data More Accessible

Medical imaging is a critical tool used to diagnose patients, and there are billions of medical images scanned globally each year. Imaging data accounts for about 90% of all healthcare data1 and, until... Read more
Copyright © 2000-2023 Globetech Media. All rights reserved.