Features | Partner Sites | Information | LinkXpress
Sign In
Schiller
ElsMed
Ampronix

Quantitative Susceptibility MR Imaging Developed to Monitor Multiple Sclerosis

By Medimaging International staff writers
Posted on 05 Jun 2014
Image: Dr. Ravi Menon, an imaging scientist at Western University’s Robarts Research Institute, used quantitative susceptibility MRI to show and measure damage in specific areas of the brain, which the study showed to be common to all MS and clinically isolated syndrome (CIS) patients (Photo courtesy of Western University).
Image: Dr. Ravi Menon, an imaging scientist at Western University’s Robarts Research Institute, used quantitative susceptibility MRI to show and measure damage in specific areas of the brain, which the study showed to be common to all MS and clinically isolated syndrome (CIS) patients (Photo courtesy of Western University).
Canadian imaging investigators have developed a better way to monitor the progression of multiple sclerosis (MS) at its earliest stages.

Led by Ravi Menon, PhD, from Western University’s Robarts Research Institute (London, Canada), the researchers used a new application called quantitative susceptibility (QS) magnetic resonance imaging (MRI), to gauge impairment in specific areas of the brain that the study showed to be common to all patients. The findings were published online May 28, 2014, in the journal Radiology.

“In MS research, there is something we call a clinical-radiological paradox. When you do conventional MRIs on these patients you see lesions in the brain very clearly, but the number or volume of their lesions do not correlate with the patients’ disabilities. This paradox has been recognized since the MRI was introduced to clinical practice in the early 80s, and yet this is the only imaging tool we have for assessing MS,” said Dr. Menon. “Our research provides a quantitative tool using a relatively conventional imaging sequence but with novel analysis. This tool shows that there is considerable damage occurring in common areas of all patients in both the white matter and in the deep brain structures—the gray matter. Those quantitative measures—what we call quantitative susceptibility—correlate with disease symptoms.”

The process used a conventional Siemens Healthcare (Erlangen, Germany) 3T MRI system so that it could be reproduced in any hospital, using the technique, called QS. The researchers mapped this MRI parameter in 25 patients with relapsing-remitting MS or clinically isolated syndrome (CIS; half of those diagnosed with CIS will go on to be diagnosed with MS) measuring both demyelination and iron deposition. Fifteen age- and sex-matched control study participants were also scanned. Whereas brain and spine lesions visualized with traditional MRI scanning tend to appear and disappear over time, QS revealed common areas of damage in all patients that correlated very well with the extended disability status score (EDSS), which is a standard approach used to measure MS progression, as well as with age and time since diagnosis.

“Significantly, in white matter, even where we see no lesions whatsoever, we’re able to measure damage in the same area of all patients using QS mapping. So even at the very earliest stages of the disease when the disability score is very low, or when the person hasn’t yet been diagnosed with MS, there’s already significant damage,” added Dr. Menon. This could have important diagnostic and prognostic implications, as there are drugs available to slow or stop the progression of MS, if initiated early enough.

Related Links:

Western University’s Robarts Research Institute
Siemens Healthcare



Channels

Radiography

view channel
Image: GE Healthcare’s Revolution EVO CT system (Photo courtesy of GE Healthcare).

CT System Improves Outcomes While Supporting Wide Range of Patients

New computed tomography (CT) technology can improve patient outcomes while cutting the cost of providing care. Revolution EVO, developed by GE Healthcare (Chalfont St. Giles, UK), is designed to support... Read more

Ultrasound

view channel
Image: UAMS researcher William Culp, MD, (right), and Doug Wilson of UALR (left) have developed a device to treat stroke (Photo courtesy of UAMS/UALR Office of Communications).

Clot-Buster Ultrasound Device May Become Best Treatment Option for Stroke Patients

A new device is being developed to treat stroke more effectively. The new technology fits on the head similar to a halo and delivers therapy to rapidly bust clots that cause stroke. The device was developed... Read more

Nuclear medicine

view channel

PET Imaging Reveals Brain Benefits from Weight Loss After Bariatric Surgery

Imaging studies revealed that weight loss surgery has been found to suppress changes in brain metabolism associated with obesity and improve cognitive function involved in planning, strategizing, and organizing. Therefore, researchers have hypothesized that a specific surgical procedure could reduce risk of Alzheimer’s... Read more

General/Advanced Imaging

view channel

Diagnostic Imaging Tests Ordered by General Practitioners in Australia Nearly Double in 10 Years

A 45% increase in diagnostic imaging tests ordered by Australian general practitioners (GPs) is being fueled by increasing GP visits, an escalating number of problems managed at doctor visits, and a higher probability that GPs order imaging tests for these problems, according to a new study. Based on a long-term national... Read more

Imaging IT

view channel
Image: An X-ray using the ClearRead bone suppression software technology (Photo courtesy of Riverain Technologies).

Bone Suppression Software Used to Optimize Diagnostic Capability of X-Ray Systems

Clinicians are gathering important information from the most routine imaging exam, the chest X-ray, by using advanced software that enhances X-ray images captured by the equipment they already have or... Read more

Industry News

view channel

Acquisition Includes Radiation Simulation Software for Radiotherapy Applications

Varian Medical Systems, Inc. (Palo Alto, CA, USA) has acquired certain assets of Transpire, Inc. (Gig Harbor, WA, USA) including the Acuros dose calculation software, which has been incorporated into Varian’s BrachyVision and Eclipse treatment planning software systems. The acquisition closed at the end of July 2014.... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.