Features | Partner Sites | Information | LinkXpress
Sign In
Ampronix
Schiller
ElsMed

Characteristic Sign Allows for MR Diagnosis of Parkinson’s Disease

By Medimaging International staff writers
Posted on 12 May 2014
Image: A shape similar to a swallow’s tail has been identified as a new and accurate test for Parkinson’s disease. The image, which depicts the healthy state of a group of cells in the subregion of the human brain, was revealed using 3T MRI scanning technology (Photo courtesy of the University of Nottingham).
Image: A shape similar to a swallow’s tail has been identified as a new and accurate test for Parkinson’s disease. The image, which depicts the healthy state of a group of cells in the subregion of the human brain, was revealed using 3T MRI scanning technology (Photo courtesy of the University of Nottingham).
An image similar in shape to the swallow’s tail [a deeply forked tail] has been identified as a new and effective way to diagnose Parkinson’s disease (PD). The image, which depicts the healthy state of a group of cells in a subregion of the human brain, was depicted using 3T magnetic resonance imaging (MRI) scanning technology—conventional equipment currently used in clinical environments.

The research was led by Dr. Stefan Schwarz and Prof. Dorothee Auer, experts in neuroradiology in the School of Medicine at the University of Nottingham (UK), and was conducted at the Queen’s Medical Center (Nottingham, UK) in collaboration with Dr. Nin Bajaj, a specialist in movement disorder diseases at the Nottingham University Hospitals National Health Service (NHS) Trust. The findings were been published April 7, 2014, in the open access academic journal PLOS one. The research builds on a successful collaboration with Prof. Penny Gowland at the Sir Peter Mansfield Magnetic Resonance Center at the University of Nottingham.

The investigators reported that the absence of this imaging sign can help to diagnose PD using conventional clinical MRI scanners. Diagnosing Parkinson’s, up to now, has been clinically uncertain. Diagnosing patients had to rely on expensive nuclear medical techniques. The diagnosis can be problematic early in the course of the condition and in tremor dominant instances. Other nonlicensed diagnostic techniques offer a varying range of accuracy, repeatability, and effectiveness but none of them have demonstrated the required accuracy and ease of use to allow conversion into standard clinical practice.

Using high resolution, ultra-high field 7T MRI technology, Nottingham research scientist had targeted the telltale pathology of Parkinson’s with structural alterations in a small area of the mid brain known as the substantia nigra. This new study has shown that these changes can also be identified using 3T MRI technology, which is accessible in hospitals across Europe and the United States. They subsequently termed the phrase the “swallow tail appearance” as an easy recognizable sign of the healthy appearing substantia nigra, which is lost in Parkinson’s disease. A total of 114 high-resolution MRI scans were reviewed and in 94% of patients the diagnosis was effectively made using this technique.

“This is a breakthrough finding as currently Parkinson’s disease is mostly diagnosed by identifying symptoms like stiffness and tremor. Imaging tests to confirm the diagnosis are limited to expensive nuclear medical techniques which are not widely available and associated with potentially harmful ionizing radiation. Using magnetic resonance imaging [MRI] we identified a specific imaging feature which has great similarity to a tail of a swallow and therefore decided to call it the ‘swallow tail sign.’ This sign is absent in Parkinson’s disease,” Dr. Schwarz concluded.

Related Links:

University of Nottingham



Channels

Radiography

view channel
Image: The Somatom Scope CT system’s biopsy and intervention modes for CT-guided intervention enhance precision and streamline workflow (Photo courtesy of Siemens Healthcare).

16-Slice CT System’s Technology Extends Operational Lifetime by Minimizing Wear and Tear

A new 16-slice computed tomography (CT) system is designed for clinical routine and is available in two power configurations to better meet clinical, workflow requirements. Siemens Healthcare (Erlangen,... Read more

Ultrasound

view channel
Image: Leading German anesthetists Drs. Wolf Armbruster, Rüdiger Eichholz, and Thomas Notheisen have collaborated to develop the Armbruster Eichholz Notheisen (AEN) training concept for ultrasound-guided regional anesthesia (Photo courtesy of Management and Krankenhaus).

Point-of-Care Ultrasound Training Program Established for Regional Anesthesiologists

Regional anesthesia specialists have developed an innovative ultrasound training program. Leading German anesthetists Drs. Wolf Armbruster, Rüdiger Eichholz, and Thomas Notheisen have collaborated to... Read more

Nuclear medicine

view channel
Image: The ProBeam system treatment room (Photo courtesy of Varian Medical Systems).

Five Proton Therapy Treatment Rooms Plus System Upgrade Deployed at Scripps Proton Therapy Center

An upgrade of a proton system will improve workflow at a US proton therapy center, enabling the use of the fixed-beam treatment rooms as well as more diverse patient-positioning devices.... Read more

General/Advanced Imaging

view channel
Image: New laser technology designed to detect breast cancer based on photoacoustics (Photo courtesy of Universidad Carlos III de Madrid).

Photoacoustics Used to Detect Breast Cancer

Spanish scientists are using new laser technology to detect breast cancer based on photoacoustics. The new approach could become an alternative to mammography or ultrasound. The European science project... Read more

Imaging IT

view channel
Image: The Clinical Data Collaboration platform uses Carestream’s intelligent vendor-neutral archive (VNA) to archive and exchange radiology, dermatology, endoscopy, and cardiology files (Photo courtesy of Carestream).

IT Systems Designed to Streamline Radiologists Workflow While Improving Patient Care

New information technology (IT) systems have been designed to help radiology professionals improve patient care, workflow, and cut costs. Carestream recently developed (Rochester, NY, USA) new capabilities... Read more

Industry News

view channel

Global Partnership Provides Treatment Planning Support for Modulated Arc Radiotherapy

Varian Medical Systems (Palo Alto, CA, USA) Eclipse treatment planning software can now be used to plan modulated arc radiotherapy (mARC) treatments at sites using Siemens Healthcare (Erlangen, Germany) medical linear accelerators. Varian Medical Systems and Siemens Healthcare presented their range of solutions that... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.