Features | Partner Sites | Information | LinkXpress
Sign In
Schiller
Agfa Healthcare
Ampronix

Characteristic Sign Allows for MR Diagnosis of Parkinson’s Disease

By Medimaging International staff writers
Posted on 12 May 2014
Image: A shape similar to a swallow’s tail has been identified as a new and accurate test for Parkinson’s disease. The image, which depicts the healthy state of a group of cells in the subregion of the human brain, was revealed using 3T MRI scanning technology (Photo courtesy of the University of Nottingham).
Image: A shape similar to a swallow’s tail has been identified as a new and accurate test for Parkinson’s disease. The image, which depicts the healthy state of a group of cells in the subregion of the human brain, was revealed using 3T MRI scanning technology (Photo courtesy of the University of Nottingham).
An image similar in shape to the swallow’s tail [a deeply forked tail] has been identified as a new and effective way to diagnose Parkinson’s disease (PD). The image, which depicts the healthy state of a group of cells in a subregion of the human brain, was depicted using 3T magnetic resonance imaging (MRI) scanning technology—conventional equipment currently used in clinical environments.

The research was led by Dr. Stefan Schwarz and Prof. Dorothee Auer, experts in neuroradiology in the School of Medicine at the University of Nottingham (UK), and was conducted at the Queen’s Medical Center (Nottingham, UK) in collaboration with Dr. Nin Bajaj, a specialist in movement disorder diseases at the Nottingham University Hospitals National Health Service (NHS) Trust. The findings were been published April 7, 2014, in the open access academic journal PLOS one. The research builds on a successful collaboration with Prof. Penny Gowland at the Sir Peter Mansfield Magnetic Resonance Center at the University of Nottingham.

The investigators reported that the absence of this imaging sign can help to diagnose PD using conventional clinical MRI scanners. Diagnosing Parkinson’s, up to now, has been clinically uncertain. Diagnosing patients had to rely on expensive nuclear medical techniques. The diagnosis can be problematic early in the course of the condition and in tremor dominant instances. Other nonlicensed diagnostic techniques offer a varying range of accuracy, repeatability, and effectiveness but none of them have demonstrated the required accuracy and ease of use to allow conversion into standard clinical practice.

Using high resolution, ultra-high field 7T MRI technology, Nottingham research scientist had targeted the telltale pathology of Parkinson’s with structural alterations in a small area of the mid brain known as the substantia nigra. This new study has shown that these changes can also be identified using 3T MRI technology, which is accessible in hospitals across Europe and the United States. They subsequently termed the phrase the “swallow tail appearance” as an easy recognizable sign of the healthy appearing substantia nigra, which is lost in Parkinson’s disease. A total of 114 high-resolution MRI scans were reviewed and in 94% of patients the diagnosis was effectively made using this technique.

“This is a breakthrough finding as currently Parkinson’s disease is mostly diagnosed by identifying symptoms like stiffness and tremor. Imaging tests to confirm the diagnosis are limited to expensive nuclear medical techniques which are not widely available and associated with potentially harmful ionizing radiation. Using magnetic resonance imaging [MRI] we identified a specific imaging feature which has great similarity to a tail of a swallow and therefore decided to call it the ‘swallow tail sign.’ This sign is absent in Parkinson’s disease,” Dr. Schwarz concluded.

Related Links:

University of Nottingham



Channels

Radiography

view channel
Image: Whole body images of a mouse before and after nanoparticles injections. Signal loss in the liver and the spleen due to the accumulation of iron from the nanoparticles is indicated by the red arrows. (Photo courtesy of Imperial College London).

Self-Assembling Nanoparticles Could Improve Cancer Diagnosis

Innovative nanoparticles boost the effectiveness of magnetic resonance imaging (MRI) scanning by specifically seeking out receptors that are found in cancerous cells. Developed by researchers at Imperial... Read more

Ultrasound

view channel
Image: The Vivid T8 cardiovascular ultrasound system offers quantitative features such as stress echo and transesophageal echocardiography (TEE) capabilities (Photo courtesy of GE Healthcare).

Mobile, Cardiovascular Ultrasound Features Stress Echo and Transesophageal Echocardiography Capabilities

A 58.5-kg mobile cardiovascular ultrasound system features innovative quantitative features such as stress echo, and transesophageal echocardiography (TEE) capabilities, designed for healthcare providers... Read more

Nuclear medicine

view channel

Proton Therapy Has Better Outcome over IMRT for Advanced Head and Neck Cancers

Radiation oncologists compared the world’s literature on outcomes of proton beam therapy in the treatment of a range of advanced head and neck cancers of the skull base compared to intensity-modulated radiation therapy (IMRT) and found that proton beam therapy significantly improved disease-free survival and tumor control... Read more

General/Advanced Imaging

view channel
Image: Participant fitted with fNIRS headgear (Photo courtesy of University of Pittsburgh Schools of the Health Sciences).

Portable Optical Imaging Tool Designed for Concussion Evaluation

Researchers have demonstrated that a portable, low-cost optical imaging application is useful in evaluation of concussions. Two separate research projects, published recently, represent important steps... Read more

Imaging IT

view channel

Virtual Finger Helps Study 3D Images Faster

A new digital navigation technology allows users to sift through three-dimensional (3D) images more efficiently and comprehensively than previous technology. The Virtual Finger (VF), developed at the Allen Institute for Brain Science (Seattle, WA, USA), aids scientists and researchers move through digital images of small... Read more

Industry News

view channel

Hosting and Distribution Collaboration Established to Provide Radiation Dose Monitoring

PHS Technologies Group, LLC (Scottsdale, AZ, USA), a unit of PACSHealth, LLC, and a developer of software that monitors patient exposure to ionizing radiation, reported that Dell Healthcare and Life Sciences (Round Rock, TX, USA) will become a marketing, distribution, and hosting partner for its DoseMonitor OnLine software.... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.