Features | Partner Sites | Information | LinkXpress
Sign In
Schiller
Demo Company
Ampronix

DTI-MRI Targets Brain Injury Region in Some Concussion Patients

By Medimaging International staff writers
Posted on 30 Apr 2014
Image: Vestibular disturbances correlate with decreased FA in cerebellar regions responsible for sensorimotor processing and central and/or axial balance as well as fusiform gyrus, which is responsible for visually guided locomotion and stereoscopic vision. Images derived from TBSS results and rendered on T1- weighted images from Montreal Neurologic Institute atlas indicate that significant white matter differences in patients with mild TBI and vestibular symptoms involve (a–c) lobule VI and vermian lobules VIIIa, VIIIb, and IX, as shown in axial (a), coronal (b), and sagittal (c) planes, and (d–f) fusiform gyri bilaterally, as shown in axial (d), coronal (e), and sagittal (f) planes. Significant voxels (p < .005, corrected for multiple comparisons) were thickened by using TBSS fill function into local tracts (red) and overlaid on white matter skeleton (blue) (Photo courtesy of Radiology).
Image: Vestibular disturbances correlate with decreased FA in cerebellar regions responsible for sensorimotor processing and central and/or axial balance as well as fusiform gyrus, which is responsible for visually guided locomotion and stereoscopic vision. Images derived from TBSS results and rendered on T1- weighted images from Montreal Neurologic Institute atlas indicate that significant white matter differences in patients with mild TBI and vestibular symptoms involve (a–c) lobule VI and vermian lobules VIIIa, VIIIb, and IX, as shown in axial (a), coronal (b), and sagittal (c) planes, and (d–f) fusiform gyri bilaterally, as shown in axial (d), coronal (e), and sagittal (f) planes. Significant voxels (p < .005, corrected for multiple comparisons) were thickened by using TBSS fill function into local tracts (red) and overlaid on white matter skeleton (blue) (Photo courtesy of Radiology).
Image: Vestibular disturbances correlate with increased mean diffusivity in vermian lobules of spinocerebellum, which processes proprioception input from spinal cord dorsal columns to anticipate future positioning during the course of a movement. Images derived from TBSS results and rendered on T1-weighted images from Montreal Neurologic Institute atlas indicate that significant white matter differences in patients with mild TBI and vestibular symptoms involve vermian lobules II and III, as shown in (a) axial and (b) sagittal planes. Significant voxels (p < 0.05, corrected for multiple comparisons) were thickened by using TBSS fill function into local tracts (red) and overlaid on white matter skeleton (blue) (Photo courtesy of Radiology).
Image: Vestibular disturbances correlate with increased mean diffusivity in vermian lobules of spinocerebellum, which processes proprioception input from spinal cord dorsal columns to anticipate future positioning during the course of a movement. Images derived from TBSS results and rendered on T1-weighted images from Montreal Neurologic Institute atlas indicate that significant white matter differences in patients with mild TBI and vestibular symptoms involve vermian lobules II and III, as shown in (a) axial and (b) sagittal planes. Significant voxels (p < 0.05, corrected for multiple comparisons) were thickened by using TBSS fill function into local tracts (red) and overlaid on white matter skeleton (blue) (Photo courtesy of Radiology).
Convergence insufficiency correlates with increased FA in right anterior thalamic radiation, which is central to processing speed, and right geniculate nucleus optic radiations, the major relay station for the accommodation circuit central to oculomotor convergence. Asymmetric involvement of the right is not unexpected, as the corresponding left visual field is dominant for spatial processing as compared with the right visual field, which is dominant for nonspatial and/or temporal processing. Images derived from TBSS results and rendered on T1-weighted images from Montreal Neurologic Institute atlas show that significant white matter differences in patients with mild TBI and convergence insufficiency involve right anterior thalamic radiation, as shown in (a) coronal and (b) axial planes, and right geniculate nucleus optic radiations; as shown in (c) coronal and (d) axial planes. Significant voxels (P < .05, corrected for multiple comparisons) were thickened by using TBSS fill function into local tracts (red) and overlaid on white matter skeleton (blue) (Photo courtesy of Radiology).
Convergence insufficiency correlates with increased FA in right anterior thalamic radiation, which is central to processing speed, and right geniculate nucleus optic radiations, the major relay station for the accommodation circuit central to oculomotor convergence. Asymmetric involvement of the right is not unexpected, as the corresponding left visual field is dominant for spatial processing as compared with the right visual field, which is dominant for nonspatial and/or temporal processing. Images derived from TBSS results and rendered on T1-weighted images from Montreal Neurologic Institute atlas show that significant white matter differences in patients with mild TBI and convergence insufficiency involve right anterior thalamic radiation, as shown in (a) coronal and (b) axial planes, and right geniculate nucleus optic radiations; as shown in (c) coronal and (d) axial planes. Significant voxels (P < .05, corrected for multiple comparisons) were thickened by using TBSS fill function into local tracts (red) and overlaid on white matter skeleton (blue) (Photo courtesy of Radiology).
Researchers using data provided by a magnetic resonance imaging (MRI) scanning technique have identified regional white matter damage in the brains of individuals who experience chronic dizziness and other symptoms after concussion. The findings suggest that information provided by MRI can speed the onset of effective treatments for concussion patients.

The study’s findings were published online April 15, 2014, in the journal Radiology.

Concussions, also known as mild traumatic brain injury (mTBI), affect between 1.8 and 3.8 million individuals in the United States yearly. One of the most common and debilitating effects of concussion is vestibulopathy, a disorder characterized by imbalance, dizziness, and visual difficulties. Vestibulopathy impairs activities of daily living and puts patients at increased risk for a second injury. Up until now, no specific brain regions have been linked to the prognosis of patients with vestibulopathy.

For the study, the researchers retrospectively reviewed imaging data from 30 mTBI patients with vestibular symptoms and 25 with ocular convergence insufficiency, a condition that occurs when the eyes do not turn inward properly when focusing on a nearby object. Controls consisted of 39 mTBI patients without vestibular abnormalities and 17 with normal ocular convergence. The imaging data were acquired using an MRI technique called diffusion tensor imaging (DTI), which produces a fractional anisotropy (FA) value that can be used to determine damage to the brain's signal-transmitting white matter.

“FA provides a measure of how intact the white matter is,” said Lea Alhilali, MD, from the University of Pittsburgh Medical Center (PA, USA). “The lower the FA value, the more injured the white matter is.”

When Dr. Alhilali and colleagues compared the DTI findings, they discovered that the concussion patients with vestibular symptoms had decreased FA values in brain regions not previously suspected to be involved in post-traumatic vestibulopathy. “Patients with vestibular symptoms had white matter injury in the cerebellar area, which is known to control balance and movement, and also in the fusiform gyri, a brain area that integrates the visual fields of the left and right eye and is important to spatial orientation,” she said.

The findings seem to demonstrate a connection between vestibulopathy and regional brain damage, Dr. Alhilali added. “Vestibulopathy was previously thought to be related to the inner ear structure,” she said. “What’s unique about our study is that it shows that, in these patients, there is also injury to the brain itself.”

The researchers also found that injury to the cerebellar area was associated with a lengthier recovery time. The findings have the potential to change the clinical management of vestibulopathy in concussion patients, Dr. Alhilali reported. DTI findings, for instance, could be used with neurocognitive testing to help determine a patient’s prognosis and begin appropriate treatments. “Vestibular therapy is often very effective,” Dr. Alhilali said. “Using DTI findings, we can treat patients earlier and get them back to a baseline state much sooner.”

The researchers have two objectives in the near term, Dr. Alhilali said. First they want to identify brain injuries associated with other postconcussion symptoms, and then they hope to conduct prospective studies to track patients from shortly after their concussions through recovery. “Concussion is not just one pathology, but many different injuries with different symptoms,” Dr. Alhilali said. “Not every case is the same, and we need to treat each patient individually.”

Related Links:

University of Pittsburgh Medical Center



Channels

Ultrasound

view channel

New Ultrasound System Enhances Patient Care and User Experience

A new ultrasound system with innovative specialized transducers and improved image quality, intended for general imaging, women’s health, and shared service applications, has been announced. The system features improved accuracy, performance, assessment tools, advanced automation, and an enhanced user experience.... Read more

Nuclear medicine

view channel

Clinical Study Shows Added Value of Amyloid PET Imaging in the Diagnosis and Treatment of Dementia

Early-onset dementia patients could benefit from a new PET imaging agent developed by a major medical imaging vendor. The results of a clinical study showing the effectiveness of the amyloid PET imaging agent were presented at the Alzheimer’s Association International Conference (AAIC 2015) in Washington DC (USA).... Read more

General/Advanced Imaging

view channel
Image: Illustration of a new technique using Optical Coherence Tomography that could help surgeons differentiate a human brain tumor, red, from surrounding noncancerous tissue, green (Photo courtesy of  Carmen Kut, Jordina Rincon-Torroella, Xingde Li and Alfredo Quinones-Hinojosa/Johns Hopkins Medicine).

Imaging Technique Helps Safer and More Effective Removal of Brain Tumors

Researchers at the Johns Hopkins University have demonstrated a new imaging technology that could enable neurosurgeons to better differentiate between healthy and cancerous brain tissue and perform safer... Read more

Imaging IT

view channel
Image: Siemens Healthcare’s syngo.via MM Oncology facilitates compliance by clinicians to British Thoracic Society guidelines for the investigation and management of pulmonary nodules.(Photo courtesy of Siemens Healthcare).

Oncology Software Update Compliant with New BTS Guidelines

A key diagnostic imaging vendor has announced that it has modified its oncology software solution to ensure compliance with new British Thoracic Society (BTS) guidelines for lung nodule screening.... Read more

Industry News

view channel

Report Forecasts Growth of Global Computed Tomography Sector to USD 6 billion by 2019

A new report has been published that analyzes global Computed Tomography (CT) market shares, strategies, and forecasts, for the years 2013 to 2018. The report entitled “Global Computed Tomography (CT) Market Shares, Strategies, and Forecasts, 2013 to 2018,” predicts that global CT markets will continue to grow moderately... Read more
 

Events

11 Sep 2015 - 12 Sep 2015
19 Sep 2015 - 24 Sep 2015
Copyright © 2000-2015 Globetech Media. All rights reserved.