We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
GLOBETECH PUBLISHING LLC

Download Mobile App




PET Imaging Technique Pinpoints Colitis Inflammation

By MedImaging International staff writers
Posted on 13 Jun 2018
Print article
Image: Ex vivo images of colons, ceca, and mesenteric lymph nodes taken via the immunoPET platform (Photo courtesy of UCLA).
Image: Ex vivo images of colons, ceca, and mesenteric lymph nodes taken via the immunoPET platform (Photo courtesy of UCLA).
A new positron emission tomography (PET) method can detect inflammation sites in people with inflammatory bowel disease (IBD), according to a new study.

Researchers at the University of California, Los Angeles (UCLA; USA) and Regeneron Pharmaceuticals (Tarrytown, NY, USA) conducted a mouse model study of colitis that used PET imaging with antibody fragment probes (immunoPET) based on GK1.5 cys-diabody (cDb) that target CD4+ T cells, a subset of immune cells characteristic of IBD. A zirconium-89 (89Zr)-labeled anti-CD4 engineered cDb probe was used for noninvasive imaging of the distribution of CD4+ T cells in mice with induced colitis.

The results revealed an increased number of CD4+ T cells in the colons of colitic mice, as confirmed by immunohistochemistry. Increased uptake of 89Zr-malDFO-GK1.5 cDb was detected in the distal colon, ceca, and mesenteric lymph nodes (MLNs) in in-vivo PET scans. Ex-vivo scans and biodistribution also confirmed the higher uptake in dextran sulfate sodium (DSS)-treated colons, ceca, and MLN. The researchers suggest that CD4 immunoPET has the potential to guide development of antibody-based imaging in humans with IBD. The study was published in the June 2018 issue of The Journal of Nuclear Medicine.

“ImmunoPET is a robust and general platform for visualization of highly specific molecular targets. CD4 immunoPET could provide a noninvasive means to detect and localize sites of inflammation in the bowel and also provide image guidance for biopsies,” said senior author Professor Anna Wu, PhD, director of the UCLA cancer molecular imaging program. “It could unlock our ability to assess inflammation in a broad spectrum of disease areas, including oncology and immune-oncology, auto-immunity, cardiovascular disease, neuroinflammation, and more.”

CD4+ T helper cells are white blood cells that are an essential part of the human immune system. They are called helper cells because one of their main roles is to send signals to other types of immune cells, including CD8 killer cells, which then destroy the infectious particle. If CD4 cells become depleted, for example in untreated HIV infection, or following immune suppression prior to a transplant, the body is left vulnerable to a wide range of infections that it would otherwise have been able to fight.

Related Links:
University of California, Los Angeles
Regeneron Pharmaceuticals
Gold Member
Solid State Kv/Dose Multi-Sensor
AGMS-DM+
New
Silver Member
Mobile X-Ray Barrier
Lead Acrylic Mobile X-Ray Barriers
Dose Area Product Meter
VacuDAP
MRI System
uMR 588

Print article

Channels

Radiography

view channel
:	Image: The AI model could be a valuable adjunct to human radiologists in breast cancer diagnoses and risk prediction (Photo courtesy of 123RF)

AI Model Predicts 5-Year Breast Cancer Risk from Mammograms

Approximately 13% of U.S. women, or one in every eight, are predicted to develop invasive breast cancer over their lifetime, with 1 in 39 women (3%) succumbing to the illness, according to the American... Read more

Nuclear Medicine

view channel
Image: The AI system uses scintigraphy imaging for early diagnosis of cardiac amyloidosis (Photo courtesy of 123RF)

AI System Automatically and Reliably Detects Cardiac Amyloidosis Using Scintigraphy Imaging

Cardiac amyloidosis, a condition characterized by the buildup of abnormal protein deposits (amyloids) in the heart muscle, severely affects heart function and can lead to heart failure or death without... Read more

Imaging IT

view channel
Image: The new Medical Imaging Suite makes healthcare imaging data more accessible, interoperable and useful (Photo courtesy of Google Cloud)

New Google Cloud Medical Imaging Suite Makes Imaging Healthcare Data More Accessible

Medical imaging is a critical tool used to diagnose patients, and there are billions of medical images scanned globally each year. Imaging data accounts for about 90% of all healthcare data1 and, until... Read more

Industry News

view channel
Image: Samsung Medison CEO Mr. Yongkwan Kim and Bracco Imaging CEO Dr. Fulvio Renoldi Bracco endorsed a MoU agreement (Photo courtesy of Bracco Group)

Samsung and Bracco Enter Into New Diagnostic Ultrasound Technology Agreement

Samsung Medison (Seoul, South Korea) and Bracco Imaging (Milan, Italy) have entered into a Memorandum of Understanding (MoU) agreement to pioneer a new area for diagnostic ultrasound devices and contrast agents.... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.