We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
GLOBETECH PUBLISHING LLC

Download Mobile App




MRI Can Halve Prostate Cancer Over-Diagnosis

By MedImaging International staff writers
Posted on 29 Jul 2021
Print article
Image: MRI screening can significantly reduce prostate cancer over-diagnoses (Photo courtesy of Getty Images)
Image: MRI screening can significantly reduce prostate cancer over-diagnoses (Photo courtesy of Getty Images)
A new study suggests that screening by magnetic resonance imaging (MRI) and targeted biopsies could significantly reduce prostate cancer (PC) over-diagnosis.

Researchers at Karolinska Institutet (Solna, Sweden) and Karolinska University Hospital (Stockholm, Sweden) conducted a population-based study of 12,750 (50 to 74 years of age). Those with prostate-specific antigen (PSA) levels of 3 ng/ml or higher were randomly assigned to undergo standard biopsy or MRI, with targeted biopsy added if MRI results suggested PC. The primary outcome was proportion of men in whom clinically significant PC was diagnosed; a key secondary outcome was the detection of clinically insignificant cancers.

The results showed that 1,532 men had PSA levels of 3 ng/ml or higher; 603 were assigned to the standard biopsy group and 929 to the targeted biopsy group. In intention-to-treat analysis, clinically significant cancer was diagnosed in 21% in the targeted biopsy group, as compared with 18% in the standard biopsy group. The percentage of clinically insignificant cancers was lower in the targeted biopsy group (4%) than in the standard biopsy group (12%). The study was published on July 9, 2021, in The New England Journal of Medicine (NEJM).

“High rates of overdiagnosis are a critical barrier to organized PC screening. Most countries have not introduced nationwide PC screening, as current methods result in over-diagnoses and excessive and unnecessary biopsies,” said lead author urologist Tobias Nordström, PhD, of Karolinska Institutet. “Our results show that modern methods for PC screening maintain the benefits of screening, while decreasing the harms substantially. This addresses the greatest barrier to the introduction of nationwide screening.”

Current PC screening methods, which include prostate-specific antigen (PSA) tests combined with traditional biopsies, often result in unnecessary biopsies, and the detection of numerous minor low-risk tumors. Consequently, no country except Lithuania has chosen to introduce a nationwide PC screening programme, as the benefits do not exceed the disadvantages.

Related Links:
Karolinska Institutet
Karolinska University Hospital


Gold Member
Solid State Kv/Dose Multi-Sensor
AGMS-DM+
New
Self-Driving Mobile C-arm
CIARTIC Move
New
Ultrasound Software
UltraExtend NX
New
Wireless Handheld Ultrasound System
TE Air

Print article

Channels

Radiography

view channel
:	Image: The AI model could be a valuable adjunct to human radiologists in breast cancer diagnoses and risk prediction (Photo courtesy of 123RF)

AI Model Predicts 5-Year Breast Cancer Risk from Mammograms

Approximately 13% of U.S. women, or one in every eight, are predicted to develop invasive breast cancer over their lifetime, with 1 in 39 women (3%) succumbing to the illness, according to the American... Read more

Nuclear Medicine

view channel
Image: The AI system uses scintigraphy imaging for early diagnosis of cardiac amyloidosis (Photo courtesy of 123RF)

AI System Automatically and Reliably Detects Cardiac Amyloidosis Using Scintigraphy Imaging

Cardiac amyloidosis, a condition characterized by the buildup of abnormal protein deposits (amyloids) in the heart muscle, severely affects heart function and can lead to heart failure or death without... Read more

General/Advanced Imaging

view channel
Image: The CIARTIC Move self-driving mobile C-arm has received FDA clearance (Photo courtesy of Siemens)

Self-Driving Mobile C-Arm Reduces Imaging Time during Surgery

Intraoperative imaging faces significant challenges due to staff shortages and the high demands placed on surgical teams in the operating room (OR). A common challenge during many OR procedures is the... Read more

Imaging IT

view channel
Image: The new Medical Imaging Suite makes healthcare imaging data more accessible, interoperable and useful (Photo courtesy of Google Cloud)

New Google Cloud Medical Imaging Suite Makes Imaging Healthcare Data More Accessible

Medical imaging is a critical tool used to diagnose patients, and there are billions of medical images scanned globally each year. Imaging data accounts for about 90% of all healthcare data1 and, until... Read more

Industry News

view channel
Image: Samsung Medison CEO Mr. Yongkwan Kim and Bracco Imaging CEO Dr. Fulvio Renoldi Bracco endorsed a MoU agreement (Photo courtesy of Bracco Group)

Samsung and Bracco Enter Into New Diagnostic Ultrasound Technology Agreement

Samsung Medison (Seoul, South Korea) and Bracco Imaging (Milan, Italy) have entered into a Memorandum of Understanding (MoU) agreement to pioneer a new area for diagnostic ultrasound devices and contrast agents.... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.