Features | Partner Sites | Information | LinkXpress
Sign In
Schiller
Ampronix
GLOBETECH PUBLISHING LLC

New Approaches for Transcanial Ultrasound Used for the Treatment of Brain Tumors and Targeted Drug Delivery

By Medimaging International staff writers
Posted on 17 Aug 2014
Image: Ultrasound image of the Circle of Willis (Photo courtesy of the Swedish Cerebrovascular Center, Seattle, WA, USA).
Image: Ultrasound image of the Circle of Willis (Photo courtesy of the Swedish Cerebrovascular Center, Seattle, WA, USA).
Image: Doppler ultrasound waveform of flow velocities in the middle cerebral artery (Photo courtesy of the Swedish Cerebrovascular Center, Seattle, WA, USA).
Image: Doppler ultrasound waveform of flow velocities in the middle cerebral artery (Photo courtesy of the Swedish Cerebrovascular Center, Seattle, WA, USA).
A study completed by a Finnish researcher provides new insights into the limitations and potential new directions for the future advancement of transcranial ultrasound therapy. Active research is ongoing in this field, which potentially can be applied to the treatment of brain tumors and targeted drug delivery.

The therapy modality has already been effectively applied to the treatment of neuropathic pain disorder and essential tremors. The benefits of transcranial ultrasound therapy include minimal invasiveness, because the treatment is delivered to the brain by transmitting ultrasound through the intact skull of the patient. The study focuses on two issues that may potentially restrict the applicability of transcranial ultrasound: skull-base heating and formation of standing-waves.

As the ultrasound beam encounters the skull bone, part of the beam’s energy is transferred into the skull as heat. In the study, it was found that the heating of the skull-base during transcranial ultrasound therapy can result in hazardous temperature elevations when the sonications are performed close to the skull-base. Three new approaches were developed in this study to counteract this potentially hazardous phenomenon.

However, standing waves are formed in the ultrasound field when waves reflect from the surface of the skull bone. During transcranial ultrasound therapy, the ultrasound amplitude can reach higher levels than intended if these reflections are not taken into account during the initial treatment planning. The study, a project that came out of a PhD thesis by Aki Pulkkinen, MSc, from the University of Eastern Finland (Joensuu), revealed that the formation of standing waves is greatly reduced when specifically designed large-area ultrasound transducers are used.

The study also introduces a model to numerically simulate clinical patient treatments performed with transcranial ultrasound therapy. The predictions produced by the model were compared to observations done in clinical patient trials performed earlier. The predictions were found to be of sufficient accuracy for an initial treatment planning. However, more accurate characterization of the acoustical and thermal parameters involved in transcranial ultrasound therapy is nonetheless required.

The Ph.D. thesis by Aki Pulkkinen, MSc, entitled Simulation Methods in Transcranial Ultrasound Therapy, is available online (please see Related Links below).

Related Links:

Simulation Methods in Transcranial Ultrasound Therapy
University of Eastern Finland



PCI Precision Charts
Supersonic Imagine
ARAB HEALTH

Channels

Radiography

view channel
Image: This shows a 3D print model used in surgical planning (Photo courtyes of RSNA).

3D Printing and CT Imaging Used to Guide Human Face Transplants

Surgeons are using computed tomography (CT) imaging and three-dimensional (3-D) printing technology to reconstruct life-size models of patients’ heads to help better control the outcome in face transplantation... Read more

MRI

view channel
Image: Head impact telemetry system (HITs) helmet-mounted accelerometers are used in youth and collegiate football to evaluate the frequency and severity of helmet impacts (Photo courtesy of RSNA).

DTI-MRI Shows Brain Alterations in High School Football Players After Only One Season

Some high school football players exhibit measurable brain alterations after only one season of play, even in the absence of concussion. The new findings were presented at the annual meeting of the... Read more

General/Advanced Imaging

view channel
Image: The DermSpectra total body digital skin imaging system (Photo courtesy of DermSpectra).

Total Body Digital Skin Imaging System Developed for Dermatology and Primary Care Practices

A total body digital skin imaging system enables physicians to track critical skin changes (skin cancers, eczema, lesions, psoriasis, and rashes) in their office, over time. The DermSpectra (Tucson,... Read more

Imaging IT

view channel

New Healthcare IT Products and Medical Imaging Systems Revealed

A wide range of new advanced information management systems and diagnostic image products aimed at improving hospital workflows and efficiency, and patient outcomes, have been revealed by a major healthcare Information Technology (IT) provider at Radiological Society of North America (RSNA 2014). The new IT offerings... Read more

Industry News

view channel

New Report Forecasts Strong Growth for Diagnostic Imaging Equipment in BRIC Countries

A new report released by MarketsandMarkets (Dallas, TX, USA) forecasts that the diagnostic imaging equipment market in Brazil, Russia, China, and India (BRIC) is expected to grow at a Compound Annual Growth Rate (CAGR) of 10.5% in the seven years between 2011 and 2018. The report covers the following diagnostic imaging... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.