Features | Partner Sites | Information | LinkXpress
Sign In
Schiller
Ampronix
GLOBETECH PUBLISHING LLC

New Approaches for Transcanial Ultrasound Used for the Treatment of Brain Tumors and Targeted Drug Delivery

By Medimaging International staff writers
Posted on 17 Aug 2014
Image: Ultrasound image of the Circle of Willis (Photo courtesy of the Swedish Cerebrovascular Center, Seattle, WA, USA).
Image: Ultrasound image of the Circle of Willis (Photo courtesy of the Swedish Cerebrovascular Center, Seattle, WA, USA).
Image: Doppler ultrasound waveform of flow velocities in the middle cerebral artery (Photo courtesy of the Swedish Cerebrovascular Center, Seattle, WA, USA).
Image: Doppler ultrasound waveform of flow velocities in the middle cerebral artery (Photo courtesy of the Swedish Cerebrovascular Center, Seattle, WA, USA).
A study completed by a Finnish researcher provides new insights into the limitations and potential new directions for the future advancement of transcranial ultrasound therapy. Active research is ongoing in this field, which potentially can be applied to the treatment of brain tumors and targeted drug delivery.

The therapy modality has already been effectively applied to the treatment of neuropathic pain disorder and essential tremors. The benefits of transcranial ultrasound therapy include minimal invasiveness, because the treatment is delivered to the brain by transmitting ultrasound through the intact skull of the patient. The study focuses on two issues that may potentially restrict the applicability of transcranial ultrasound: skull-base heating and formation of standing-waves.

As the ultrasound beam encounters the skull bone, part of the beam’s energy is transferred into the skull as heat. In the study, it was found that the heating of the skull-base during transcranial ultrasound therapy can result in hazardous temperature elevations when the sonications are performed close to the skull-base. Three new approaches were developed in this study to counteract this potentially hazardous phenomenon.

However, standing waves are formed in the ultrasound field when waves reflect from the surface of the skull bone. During transcranial ultrasound therapy, the ultrasound amplitude can reach higher levels than intended if these reflections are not taken into account during the initial treatment planning. The study, a project that came out of a PhD thesis by Aki Pulkkinen, MSc, from the University of Eastern Finland (Joensuu), revealed that the formation of standing waves is greatly reduced when specifically designed large-area ultrasound transducers are used.

The study also introduces a model to numerically simulate clinical patient treatments performed with transcranial ultrasound therapy. The predictions produced by the model were compared to observations done in clinical patient trials performed earlier. The predictions were found to be of sufficient accuracy for an initial treatment planning. However, more accurate characterization of the acoustical and thermal parameters involved in transcranial ultrasound therapy is nonetheless required.

The Ph.D. thesis by Aki Pulkkinen, MSc, entitled Simulation Methods in Transcranial Ultrasound Therapy, is available online (please see Related Links below).

Related Links:

Simulation Methods in Transcranial Ultrasound Therapy
University of Eastern Finland



Channels

Radiography

view channel

Pioneer in Orthopedic Imaging to Provide Novel Online 3-D Modeling Service for Hospitals

A company that pioneered 2-D/3-D orthopedic medical imaging has announced a new personalized 3-D image modeling service using stereo-radiographic patient images, for hospitals and healthcare professionals worldwide. The service will be able to generate 3-D models, and related clinical data, to support therapeutic decision... Read more

MRI

view channel
Image: GE Healthcare SIGNA Explorer Lift MRI Scanner (Photo courtesy of GE Healthcare).

Field Upgrades for 1.5-T MRI Systems Saves Up to Half on Replacement Costs

One of the largest global providers of medical technologies and services is offering a field upgrade program to rapidly, and economically upgrade existing customers’ 1.5-T Magnetic Resonance Imaging (MRI) scanners.... Read more

Nuclear medicine

view channel

Human Prostate Cancer Study Evaluates New Imaging Biomarker

The results of the first human prostate cancer study intended to evaluate a 2nd generation fluorine-18 labeled small-molecule PSMA inhibitor, have been published in the April 28, 2015, issue of the Journal of Molecular Imaging and Biology. The results of the evaluation demonstrated the initial safety, bio-distribution,... Read more

General/Advanced Imaging

view channel

Global Healthcare Study of Coronary Artery Disease Reaches Significant Milestone

A major milestone has been reached in the Lipid-Rich Plaque (LRP) study, a prospective, multicenter clinical trial with the potential to reveal breakthrough correlations between Lipid-Rich Plaques and occurrence of heart attacks. The LPR study has now enrolled 1,000 patients, and aims to identify a correlation between... Read more

Imaging IT

view channel
Image: Clinical Collaboration Platform (Photo courtesy of Carestream Healthcare).

New, Advanced Medical Imaging and Healthcare IT Products Showcased in HIT Expo in Paris

A medical imaging systems and Information Technology (IT) solutions provider has demonstrated its advanced imaging IT platform and product updates at Health-IT (HIT) Expo 2015 on May 19–21, in Paris (France).... Read more

Industry News

view channel

Advanced Medical Imaging Startup Company Receives Venture Funding

Zebra Medical Vision (Kibbutz Shfayim, Israel) has received an USD 8 million investment from Khosla Ventures (Menlo Park, CA, USA) to double its team, set up headquarters in the US and increase its scope of work to integrate data from additional Health Maintenance Organizations (HMO). Zebra Medical has already partnered... Read more
 
Copyright © 2000-2015 Globetech Media. All rights reserved.