Features | Partner Sites | Information | LinkXpress
Sign In
Ampronix
Schiller
Agfa Healthcare

Focused Ultrasound Technology Improves Myocardial Remodeling after Heart Attack

By Medimaging International staff writers
Posted on 05 Mar 2013
German scientists have revealed encouraging findings that allows the morphologic and functional sequelae of a myocardial infarction to be reduced. Tiny gas bubbles are forced to oscillate within the heart using focused ultrasound, which improves microcirculation and decreases the size of the scar tissue. Following myocardial infarction, the findings revealed that the lab mice have improved cardiac output using this technology, as compared to untreated animals.

The study’s findings were published online February 25, 2013, in the journal PLOS ONE. In Germany, about 280,000 people suffer a myocardial infarction per year; more than 52,000 die as a result. Due to an occluded vessel, parts of the heart muscle no longer have sufficient circulation and the tissue dies off. These areas are not replaced by new heart muscle cells but instead by scar tissue—this typically causes the pump function of the heart to decrease after a heart attack. Scientists from the Bonn University Hospital the Bonn University Hospital Bonn University Hospital (Germany) have tested the technology on mice with which scar tissue can be reduced and cardiac output increased.

“There are attempts to treat the scar tissue with gene therapy or stem cells—by contrast, we have chosen a physical approach to treatment,” reported adjunct professor Dr. med. Alexander Ghanem, from the department of cardiology of the Bonn University Hospital Bonn University Hospital. The researchers injected a total of 17 mice that had earlier had a myocardial infarction with microscopically small, gas-filled bubbles in the bloodstream. Once the microbubbles reached the heart, they were made to vibrate there using focused ultrasound. “Through this mechanical stimulation, the circulation of the area of the infarction is improved—and the scar shrinks,” Dr. Ghanem noted.

The scientists compared the findings of the mice treated with the microbubbles to those of a control group. Two weeks after the myocardial infarction, there was predicted worsening of heart function in the control group due to the maturing of the scar tissue. In contrast, the mice treated with the microbubbles did not develop any cardiac insufficiency. Jonas Dörner, the first author of the study, summarized the results, “The pumping function was significantly better in the treated animals as compared to the control group; there was also a significantly smaller amount of decayed heart muscle tissue.”

The scientists searched for the causes of these promising results, which, however, up to now, are unclear. Following ultrasound treatment of the mice, it was shown that the amount of the body’s own growth hormones significantly increased in the heart. “This is evidently the reason why the scar formation decreased as a result of the oscillating microbubbles,” said Dr. Ghanem. The scientists now hope that humans will also be able to ultimately be treated with the microbubble-ultrasound technique; however, additional study is still needed. “Potentially, all patients who have had an acute myocardial infarction are eligible for this follow-up treatment.” explained Dr. Ghanem. Microbubbles are already used as a contrast imaging agent.

The study, conducted with support from the BONFOR funding program of the Medical Faculty of Bonn University and the German Heart Foundation [Deutsche Herzstiftung e.V.], gave rise to a patent application. “Together with the company Philips Medical [Best, The Netherlands], we developed a novel ultrasonic probe which enables a standardized impulse discharge in the heart,” Dr. Ghanem stated.

The two ultrasound sources linked together are contained in one hybrid ultrasonic probe: one with low frequency for the focused stimulation of the microbubbles in the target organ and one with higher frequency for imaging. In this manner, it can be very precisely determined where the scar tissue and the microbubbles are located. “This study demonstrates again that university research inspires technological developments in medicine,” stated Dr. Ghanem.

Related Links:
Bonn University Hospital
Philips Healthcare


Channels

Radiography

view channel
Image: Changing CT scanners shape in response to patient waistlines. The CT imaging systems of today have up to 300 kg table weight allowance, 2 x 120 kW power, and an 80-cm bore (Photo courtesy of Siemens Healthcare).

Changing the Shape of CT Scanners in Response to Patient’s Expanding Waistlines

As computed tomography (CT) imaging systems continue to grow in size, weight capacity and ability to adapt for the growing waistline of patient population is essential. A recent evaluation, performed... Read more

MRI

view channel
Image: Amyloid plaques showing up in retinal scan as fluorescent spots as curcumin binds to them (Photo courtesy of CSIRO).

Retinal Imaging Detects Changes Associated with Alzheimer's Disease

A noninvasive optical imaging device can provide early detection of changes that later occur in the brain and are a classic sign of Alzheimer's disease (AD), according to a new study. Researchers at... Read more

Nuclear medicine

view channel
Image: PET scans highlight the loss of dopamine storage capacity in Parkinson’s disease. In the scan of a disease-free brain, made with [18F]-FDOPA PET (left image), the red and yellow areas show the dopamine concentration in a normal putamen, a part of the mid-brain. Compared with that scan, a similar scan of a Parkinson’s patient (right image) shows a marked dopamine deficiency in the putamen (Photo courtesy of the Feinstein Institute’s Center for Neurosciences).

Identifying Brain Networks Using Metabolic Brain Imaging-Based Mapping Strategy

A new image-based strategy has been used to identify and gauge placebo effects in randomized clinical trials for brain disorders. The researchers employed a network mapping technique to identify specific... Read more

General/Advanced Imaging

view channel

Diagnostic Imaging Tests Ordered by General Practitioners in Australia Nearly Double in 10 Years

A 45% increase in diagnostic imaging tests ordered by Australian general practitioners (GPs) is being fueled by increasing GP visits, an escalating number of problems managed at doctor visits, and a higher probability that GPs order imaging tests for these problems, according to a new study. Based on a long-term national... Read more

Imaging IT

view channel

IT Technology Unifies Images, Data, and Reporting Workflows Throughout Hospital Enterprise

A new integrated information technology (IT) system will unify images, data, and reporting workflows across all imaging departments in a hospital. The technology will allow hospitals to expand towards the latest, advanced imaging technology platform. Az Groeninge Hospital (Kortrijk, Belgium) has chosen to replace its... Read more

Industry News

view channel

Hosting and Distribution Collaboration Established to Provide Radiation Dose Monitoring

PHS Technologies Group, LLC (Scottsdale, AZ, USA), a unit of PACSHealth, LLC, and a developer of software that monitors patient exposure to ionizing radiation, reported that Dell Healthcare and Life Sciences (Round Rock, TX, USA) will become a marketing, distribution, and hosting partner for its DoseMonitor OnLine software.... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.