Features | Partner Sites | Information | LinkXpress
Sign In
Schiller
Ampronix
ElsMed

Ultrasound Screening Effective for Second Trimester Markers for Down’s Syndrome

By Medimaging International staff writers
Posted on 11 Feb 2013
A new analysis has found that some second trimester markers for Down’s syndrome that are detected by ultrasound are more important than other markers for the disease. Insights from this research should help adjust pregnant women’s risks for having a child with the disorder.

Down’s syndrome screening is offered to all pregnant women, starting with a background risk based on their age. Specific characteristics identified during a second trimester ultrasound scanning are possible markers for Down’s syndrome, and they include increased thickness of the back of the neck, dilated brain ventricles, absent or small nose bone, an abnormal artery to the upper extremities, bright spots in the heart, “bright” bowels, mild kidney swelling, and shortening of an arm bone or thigh bone.

To determine how these markers affect risk, Kypros Nicolaides, MD, from the Harris Birthright Research Center for Fetal Medicine at King’s College London (UK), and his colleagues analyzed all published data that reported findings on second trimester markers for Down’s syndrome between 1995 and 2012. The findings were published early online January 24, 2013, in the journal Ultrasound in Obstetrics & Gynecology.

The researchers identified 48 studies, and they discovered that most single markers have only a small effect on modifying the risks for Down’s syndrome. This finding could have important clinical implications because currently in the United States, when a marker such as a thighbone or short arm is identified, women are told that they are at high risk of having a child with Down’s syndrome. However, Dr. Nicolaides and his coworkers discovered that a few markers do carry increased risks. Increased thickness of the back of the neck, dilated brain ventricles, and an abnormal artery to the upper extremities increase the risk by three- to four-fold, and an absent or small nose bone increases the risk by six- to seven-fold.

“The detection of any one of the findings during the scan should prompt the sonographer to look for all other markers or abnormalities,” said Prof. Nicolaides. He added that the study also revealed that if a detailed second trimester ultrasound scan shows the absence of all major markers, the risk of having an infant affected by Down’s syndrome is decreased by more than seven-fold.

The study findings implied that the comparative significance of ultrasound markers is very different from what has been earlier believed. Prof. Nicolaides noted that these findings will be incorporated in obstetric ultrasound scan software that adjusts women’s risks for having a child with Down’s syndrome.

Related Links:
Harris Birthright Research Centre for Fetal Medicine at King’s College London



Channels

Radiography

view channel

Better Way Found to Control Lung Cancer Using Radiotherapy

British scientists discovered how to safely increase the radiotherapy dose administered to lung cancer patients, potentially offering improved local control and survival. Conventional treatment for locally advanced non-small-cell lung cancer is a combination of radiotherapy and chemotherapy. Typically, this is planned... Read more

MRI

view channel
Image: T1, T2 and T2 myocardial tissue quantification in one solution, on the fly. Based on HeartFreeze Inline Motion Correction (Siemens unique), MyoMaps1 provides pixel-based myocardial quantification. Global, diffuse, myocardial pathologies can be better detected (T1 Map), or better depict cardiac edema (T2 Map) and improve early detection of iron overload (T2 Map) (Photo courtesy of Siemens Healthcare).

New Cardiology Imaging Tools Include MRI Myocardial Tissue Quantification Tool and to Help Fight Cardiovascular Diseases

New imaging tools have been designed for a more precise diagnosis of cardiovascular diseases using computed tomography (CT), magnetic resonance imaging (MRI), and molecular imaging, as well as utilizing... Read more

Nuclear medicine

view channel

PET Imaging Reveals Brain Benefits from Weight Loss After Bariatric Surgery

Imaging studies revealed that weight loss surgery has been found to suppress changes in brain metabolism associated with obesity and improve cognitive function involved in planning, strategizing, and organizing. Therefore, researchers have hypothesized that a specific surgical procedure could reduce risk of Alzheimer’s... Read more

General/Advanced Imaging

view channel
Image: From left, Guy Genin, PhD, John Boyle and Stavros Thomopoulos, PhD, watch as a sample is exposed to stress and force. They have developed algorithms that may lead to the ability to identify weak spots in tendons, muscles and bones (Photo courtesy of Washington University in St. Louis).

Image Analysis Algorithms Devised to Find Weak Spots in Muscles, Tendons, and Bones prone to Tearing, Breaking

Researchers have developed algorithms to detect weak spots in muscles, tendons, and bones predisposed to tearing or breaking. The technology, which needs to be further refined before it is used in patients,... Read more

Imaging IT

view channel

Interactive Dashboard and Visualization Tool Designed for Oncologists

A new tool has been developed to help users of an information system for radiation oncology to analyze data and use metrics to help make more informed decisions. Varian Medical Systems (Palo Alto CA, USA), a developer of cancer treatment technology and informatics software for managing comprehensive cancer clinics, will... Read more

Industry News

view channel

USD 12 Billion Out of Total Spent on Medical Imaging Squandered in the US

The United States wastes close to USD 12 billion on unnecessary medical imaging yearly, according to a new survey of 196 hospital leaders. Smart data company peer60 (American Fork, UT, USA) surveyed 196 healthcare leaders about medical imaging in less than two weeks and found a number of reasons for the squandered resources.... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.