Features | Partner Sites | Information | LinkXpress
Sign In
Schiller
TeraRecon
VIEWORKS

CT Texture Tumor Analysis May Become Useful Biomarker for Localized Esophageal Cancer

By Medimaging International staff writers
Posted on 20 Feb 2013
Computed tomography (CT) texture analysis of primary tumors may become a helpful imaging biomarker in localized esophageal cancer after administering neoadjuvant chemotherapy, according to recent research.

The study’s findings were presented February 9, 2013, at the 2013 Cancer Imaging and Radiation Therapy Symposium, held in Orlando (FL, USA). This symposium is sponsored by the American Society for Radiation Oncology (ASTRO) and the Radiological Society of North American (RSNA).

This study assessed the tumoral texture analysis on baseline and post-treatment CT scans of 31 patients with localized resectable esophageal cancer, with a median age of 63, and who received neoadjuvant chemotherapy between 2007 and 2010. CT scans were performed before and after the use of chemotherapy and before surgery. All patients received fluorouracil-based and platinum chemotherapy followed by surgery. Texture parameters (mean-gray level intensity [MGI], entropy, uniformity, skewness, kurtosis, and standard deviation of histogram [SDH]) were derived for four filter values to highlight structures of different spatial width: 1.0 (fine texture), 1.5–2.0 (medium), and 2.5 (coarse). Median follow-up was 21.9 months. Primary tumors became more homogenous following chemotherapy because entropy decreased and uniformity increased. Smaller change in skewness following chemotherapy was a key prognostic factor—median overall survival was 36.1 months vs. 11.1 months. Lower baseline entropy and lower post-treatment MGI were also tied with increased survival, although they demonstrated only a trend toward significance.

Texture analysis of the CT scans is a post-processing step, which was performed using exclusive software (TexRAD) that enriches the images in ultrafine clarity not visible to the human eye. Specific tumoral characteristics changed consistently following chemotherapy, and some features were linked with overall survival.

“Though these results are for a very small number of patients, they suggest that the tumoral texture features may provide valuable information that could help us to distinguish which patients will do well following chemotherapy and which ones will do poorly,” concluded Connie Yip, MD, the lead study author, a clinical research fellow at King’s College London (UK), and an associate consultant in radiation oncology at the National Cancer Center, Singapore. “As a biomarker for treatment efficacy, this technique could save patients from unnecessary surgery and provide more definitive guidance in developing patient treatment plans with improved outcomes.”

Related Links:

King’s College London




Channels

Ultrasound

view channel

Study Suggests Ultrasound Could Eliminate Breast Biopsies in Adolescent Girls

Results of a study published in the Journal of Ultrasound in Medicine in April 2015, indicate that ultrasound examinations could replace invasive excisional tissue biopsies for adolescent girls with breast lumps. The study was carried out by researchers at the Loyola University Health System (Maywood, IL, USA) and included... Read more

Nuclear medicine

view channel

Funding Approved for Major New Study on the Value of PET Scans for Alzheimer's Disease

A new four-year trial with an estimated budget of USD 100 million has been announced by the US Alzheimer's Association (Chicago, IL, USA), and the American College of Radiology (ACR; Reston, VA, USA). The Imaging Dementia—Evidence for Amyloid Scanning (IDEAS) study will try to assess the value of diagnosing Alzheimer's... Read more

General/Advanced Imaging

view channel
Image: Measuring the Magnetic Activity in the Brain of a Child, Using a MEG machine. (Photo courtesy of Children\'s Hospital of Philadelphia).

Study Suggests Language Delay Linked to Chromosome Deletion in Children with Neurological Disorders

A study found that children with neuro-developmental problems born with DNA duplications or deletions on part of chromosome 16, show measurable delays in their ability to process sound and language.... Read more

Imaging IT

view channel
Image: A new imaging techniques to see how brain cancer cells (the darker gray on the bottom of the large image above) take in gold nanorod treatment (the small gray specks). The four magnified images on the right show how the cell takes up the treatment across a span of 30 seconds (Photo courtesy of VirginiaTech).

Novel Imaging Technique Visualizes Potential Cancer Treatments in Action

A new and innovative imaging technique for observing cancer treatments in brain tumor cells has been developed by researchers at the Virginia Tech Carilion Research Institute (Roanoke, VA, USA).... Read more

Industry News

view channel

Partnership to Extend Web and Mobile Image Access to Enterprise Patient Multimedia Manager

A partnership and distribution agreement has been agreed to integrate an enterprise multimedia Picture Archiving and Communication System (PACS) with an enterprise image viewing solution. The partnership will provide extended web and mobile access for clinicians to medical images and multimedia files from desktop computers,... Read more
 
Copyright © 2000-2015 Globetech Media. All rights reserved.