Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Ampronix

Early PET-Negative Stage I/II Hodgkin Lymphoma Patients Show Increased Risk of Early Relapse when Radiotherapy Is Not Used

By Medimaging International staff writers
Posted on 23 Apr 2014
Print article
Image: Micrograph of Hodgkin lymphoma. Lymph node fine-needle aspiration (FNA) specimen. Field stain (Photo courtesy of Wikimedia Commons).
Image: Micrograph of Hodgkin lymphoma. Lymph node fine-needle aspiration (FNA) specimen. Field stain (Photo courtesy of Wikimedia Commons).
Analysis of a new study indicates an increased risk of early relapse when excluding radiotherapy in early positron emission tomography (PET) scan-negative patients with stage I/II Hodgkin’s lymphoma.

The interim analysis of the intergroup EORTC-LYSA-FIL 20051 H10 trial was published online March 17, 2014, in the Journal of Clinical Oncology. Early outcome, however, was excellent in both arms, and the final analysis should reveal whether these preliminary findings are upheld over time.

Dr. J.M.M. Raemaekers, from the Radboud University Medical Center (Nijmegen, The Netherlands), and central coordinator of the study stated, “The standard treatment for patients with clinical stage I/II Hodgkin’s lymphoma is ABVD [adriamycin, bleomycin, vinblastin and dacarbazin] chemotherapy followed by radiotherapy. Striking the right balance between initial cure through combined modality treatment and accepting a higher risk of late complications, and a higher recurrence rate after omitting radiotherapy in subsets of patients who will subsequently need intensive salvage treatment, is a matter of unsettled debate.”

The main objective of the H10 trial was to evaluate whether involved-node radiotherapy could be omitted without loss of efficacy in terms of progression-free survival in patients with stage I/II Hodgkin’s lymphoma who had a negative early PET scan after two cycles of ABVD chemotherapy. This interim trial analysis included a total of 1,137 patients with untreated clinical stage I/II Hodgkin’s lymphoma. Of these, 444 patients had favorable and 693 unfavorable prognoses. Patients in each prognostic group were randomized between standard and experimental treatment and first received two cycles of ABVD chemotherapy. Patients in the experimental arm who attained a negative early PET scan after the two cycles of ABVD chemotherapy were spared involved-node radiotherapy.

One progression occurred in the standard arm and nine progressions occurred in the research arm, for patients with a favorable prognosis and a negative early PET scan. For patients with unfavorable prognosis and a negative early PET scan, seven events occurred in the standard arm and 16 events occurred in the research arm. Even though there were few events and the median follow-up time short, the Independent Data Monitoring Committee concluded it was unlikely that the final results would show noninferiority for the experimental treatment. They, therefore, advised that randomization should be stopped for early PET-negative patients.
The study was closed for recruitment in June 2011 with a total of 1952 patients. The intergroup EORTC 20051 H10 trial is coordinated by the EORTC Lymphoma Group in collaboration with the LYmphoma Study Association (LYSA) and the Fondazione Italiana Linfomi (FIL). It is being conducted in 159 sites in eight countries: Belgium, Croatia, Denmark, France, Italy, Slovakia, Switzerland, and The Netherlands.

Related Links:

Radboud University Medical Center



Print article
PHS Technologies

Channels

Radiography

view channel

Surge in CT Scans for Patients with Minor Injuries

A new study reveals that almost twice as many patients with non-serious injuries are undergoing computerized tomography (CT) scans in the emergency department (ED) compared to a decade ago. Researchers at the University of California, San Francisco (UCSF; USA) and Stanford University (CA, USA) conducted a retrospective... Read more

MRI

view channel
Image: Correlated MR and UM stack 3 weeks after GL261 tumor implantation (Photo courtesy of eLife).

Imaging Toolkit Helps Identify Brain Tumor Drug Targets

A combined magnetic resonance imaging (MRI) and ultramicroscopy (UM) toolkit could help study vessel growth as an aid in glioblastoma therapies, according to a new study. Researchers at the University... Read more

Ultrasound

view channel
Image: EMG (in blue) shows the contra-lateral evoked response at different acoustic pressure levels of FUS-induced stimulation (squared waveform) (Photo courtesy of Elisa Konofagou/Columbia Engineering).

DARPA Grant for Advanced Focused Ultrasound Research

The US Defense Advanced Research Projects Agency (DARPA) has set up a new program to advance research into focused ultrasound and improve physical and mental health using targeted stimulation of peripheral nerves.... Read more

General/Advanced Imaging

view channel

Healthcare IT Manufacturer and Teleradiology Interoperability Expert Introduce New FHIR System

A new interoperability system that was launched at the 2015 Radiological Society of North America (RSNA) annual meeting in Chicago, USA, in November, 2015, is now being introduced into the market. The system enables seamless integration of third party enterprise imaging systems using the latest Fast Healthcare Interoperability... Read more

Imaging IT

view channel
Image: Photo of the virtual reality device mobile diagnostic imaging (Photo courtesy of RSNA).

Prototype of Virtual Reality Device with Potential for Diagnostic Imaging Presented

A prototype of a high-resolution mobile Virtual Reality (VR) diagnostic imaging device for radiologists was presented at the annual Radiological Society of North America (RSNA 2015) meeting in Chicago (IL, USA).... Read more

Industry News

view channel

Radiology Oncology Surgical Robot Devices Sector Could Reach USD 7.3 Billion by 2022

A new report has been published indicating that worldwide market for radiology oncology surgical robots market is growing mainly due to an aging world population, and the benefits the new technology can offer. Radiology oncology surgical robot technology provides opportunities to change cancer treatment methods, including... Read more
Copyright © 2000-2016 Globetech Media. All rights reserved.