Features | Partner Sites | Information | LinkXpress
Sign In
TERARECON, INC.
AMPRONIX
SCHILLER AG

Hepatic Function SPECT Testing Before and During Radiotherapy Can Help in Treatment Planning for Liver Cancer Patients

By Medimaging International staff writers
Posted on 26 Feb 2013
Monitoring the hepatic function of unresectable liver cancer patients evaluated by 99mTc-labeled iminodiacetic acid (HIDA) used with single-photon emission computed tomography (SPECT) imaging before and during radiation therapy provides critical data that could guide more customized treatment plans and reduce risks of liver injury, according to recent research.

The study’s findings were presented at the 2013 Cancer Imaging and Radiation Therapy Symposium, held February 8–9, 2013, in Orlando (FL, USA). This Symposium is sponsored by the American Society for Radiation Oncology (ASTRO; Fairfax, VA, USA) and the Radiological Society of North American (RSNA; Oak Brook, IL, USA). This research included 14 patients who had unresectable intrahepatic tumors and were treated with three-dimensional conformal radiation therapy (3D CRT), intensity-modulated radiation therapy (IMRT) or stereotactic body radiation therapy (SBRT) at a median dose of 52 Gy. Patients underwent HIDA SPECT scanning prior to radiation therapy, after delivery of 50%–60% of the planned doses and one month after completion of radiation therapy. Moreover, indocyanine green tests, a measure of overall liver function, were performed +/- one day of each SPECT scan. The 27 dynamic HIDA SPECT volumes were captured over a 60-minute period after the administration of 10 mCi 99mTc-labeled HIDA on a SPECT/CT scanner.

Gauging the regional liver function prior to radiation therapy allows assessment of the precondition of the patient’s liver function. Assessing the change of the regional liver function during the mid-course of radiation therapy indicates the response of the individual patient’s liver to radiation doses. Integrating the planned radiation doses with the regional liver function evaluation and reassessment, the researchers devised a model to predict the regional liver function postradiation therapy. This information is key to providing patients with the optimal radiation doses for better tumor control, while minimizing the risk for each patient.

“Through this assessment method, patients could potentially receive more treatment doses tailored to meet their needs, based on their liver function,” said Hesheng Wang, PhD, the lead study author and a postdoctoral fellow in radiation oncology at the University of Michigan in (Ann Arbor, MI, USA). “The physiological adaptation of radiation therapy based upon individual response assessment is a valuable new paradigm worth additional testing.”

Related Links:

University of Michigan



RTI ELECTRONICS AB
SuperSonic Imagine
RADCAL

Channels

MRI

view channel

Use of Breast MRI Offers Optimized Care

Magnetic resonance imaging (MRI) is being used increasingly for breast cancer screening, diagnostic assessment, treatment planning, and monitoring; however, a recent study revealed that over time, the indication for breast MRI has changed. Much of the increase was found among women with breast cancer risk factors, but there... Read more

Ultrasound

view channel
Image: Siemens Healthcare has launched the HELX Evolution, the newest iteration of its Acuson S range of ultrasound imaging systems (Photo courtesy of Siemens Healthcare).

Ultrasound Imaging System Enhancements Include High Definition Transducers, Sophisticated Elastography, and Tissue Strain Analysis

New features designed for a range of ultrasound systems include enhanced image quality with a large 21.5-inch liquid crystal diode (LCD) monitor, high definition (HD) transducers, optimized contrast agent... Read more

General/Advanced Imaging

view channel

Secondary Light Emission Generated by Plasmonic Nanostructures May Improve Medical Imaging Technology

New clues into light emission at different wavelengths generated by elements known plasmonic nanostructures may help to improve medical imaging technology. A plasmon is a quantum of plasma oscillation. The plasmon is a quasiparticle resulting from the quantization of plasma oscillations just as photons, and phonons are... Read more

Imaging IT

view channel

Collaboration for Development of Integrated RIS/PACS

A cost-efficient radiology information systems/ picture archiving and communications system (RIS/PACS) provides turnkey installation and excellent system performance. Aycan (Rochester, NY, USA), a developer of medical imaging products, in conjunction with its business partner, medQ (Dallas, TX, USA), a developer of... Read more

Industry News

view channel

Collaboration Expands Capacity for Proton Therapy Clinical Research and Patient Treatments

Varian Medical Systems (Palo Alto, CA, USA) and the Paul Scherrer Institute (PSI; Villigen PSI, Switzerland) are extending an existing collaboration in the field of proton therapy to offer patients more accurate cancer treatments using intensity-modulated proton therapy (IMPT). Under the agreement, Varian will also... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.