Features | Partner Sites | Information | LinkXpress
Sign In
Schiller
Ampronix
ElsMed

Self-Assembling Nanoparticles Could Optimize MRI Scanning for Diagnosis of Cancer

By Medimaging International staff writers
Posted on 06 Aug 2014
Image: A nanoparticle developed by researchers at Imperial College London could boost the effectiveness of MRI scanning by zeroing in on receptors found in cancerous cells (Photo courtesy of Imperial College London).
Image: A nanoparticle developed by researchers at Imperial College London could boost the effectiveness of MRI scanning by zeroing in on receptors found in cancerous cells (Photo courtesy of Imperial College London).
To help clinicians diagnose cancer earlier, scientists have designed a new self-assembling nanoparticle that targets tumors.

The new nanoparticle, developed by researchers from Imperial College London (UK), enhances the effectiveness of magnetic resonance imaging (MRI) scanning by specifically seeking out receptors that are found in cancerous cells.

The nanoparticle is coated with a specialized protein, which searches for specific signals given off by tumors, and when it finds a tumor, it begins to interact with the cancerous cells. This interaction shreds off the protein coating, causing the nanoparticle to self-assemble into a much larger particle so that it is more visible on the scan.

The new study published July 2014 in the journal Angewandte Chemie, used cancer cells and mouse models to compare the effects of the self-assembling nanoparticle in MRI scanning against commonly used imaging agents and found that the nanoparticle produced a more powerful signal and created a clearer MRI image of the tumor. The scientists noted that the nanoparticle increases the sensitivity of MRI scanning and will ultimately enhance the physician’s ability to detect cancerous cells at much earlier stages of development.

Prof. Nicholas Long, from the department of chemistry at Imperial College London, reported that the findings show real potential for improving cancer diagnosis. “By improving the sensitivity of an MRI examination, our aim is to help doctors spot something that might be cancerous much more quickly. This would enable patients to receive effective treatment sooner, which would hopefully improve survival rates from cancer. MRI scanners are found in nearly every hospital up and down the country and they are vital machines used every day to scan patients’ bodies and get to the bottom of what might be wrong. But we are aware that some doctors feel that even though MRI scanners are effective at spotting large tumors, they are perhaps not as good at detecting smaller tumors in the early stages.”

The newly designed nanoparticle provides a tool to improve the sensitivity of MRI scanning, and the scientists are now working to enhance its effectiveness. Prof. Long said, “We would like to improve the design to make it even easier for doctors to spot a tumor and for surgeons to then operate on it. We’re now trying to add an extra optical signal so that the nanoparticle would light up with a luminescent probe once it had found its target, so combined with the better MRI signal it will make it even easier to identify tumors.”

Before evaluating and injecting the nontoxic nanoparticle into mice, the scientists had to make certain that it would not become so large when it self-assembled that it would cause damage. They injected the nanoparticle into a saline solution inside a lab petri dish and tracked its growth over a four-hour period. The nanoparticle grew from 100-800 nm—still small enough to not cause any harm.

The scientists are now improving the nanoparticle and hope to assess their design in a human trial within the next three to five years.

Dr. Juan Gallo, from the department of surgery and cancer at Imperial College London, said, “We’re now looking at fine tuning the size of the final nanoparticle so that it is even smaller but still gives an enhanced MRI image. If it is too small the body will just secrete it out before imaging, but too big and it could be harmful to the body. Getting it just right is really important before moving to a human trial.”

Related Links:

Imperial College London



Channels

Radiography

view channel

Analysis Tool Shows Proton Therapy Less Expensive Than IMRT for Advanced Head and Neck Cancers

The episodic cost of care using intensity-modulated proton therapy (IMPT) in advanced stage head and neck cancer is less expensive than intensity-modulated radiotherapy (IMRT), according to new findings. The new proof-of-concept study uses a cost analysis tool that can be used to outline the value of competing healthcare... Read more

Nuclear medicine

view channel

PET Imaging Reveals Brain Benefits from Weight Loss After Bariatric Surgery

Imaging studies revealed that weight loss surgery has been found to suppress changes in brain metabolism associated with obesity and improve cognitive function involved in planning, strategizing, and organizing. Therefore, researchers have hypothesized that a specific surgical procedure could reduce risk of Alzheimer’s... Read more

General/Advanced Imaging

view channel
Image: From left, Guy Genin, PhD, John Boyle and Stavros Thomopoulos, PhD, watch as a sample is exposed to stress and force. They have developed algorithms that may lead to the ability to identify weak spots in tendons, muscles and bones (Photo courtesy of Washington University in St. Louis).

Image Analysis Algorithms Devised to Find Weak Spots in Muscles, Tendons, and Bones prone to Tearing, Breaking

Researchers have developed algorithms to detect weak spots in muscles, tendons, and bones predisposed to tearing or breaking. The technology, which needs to be further refined before it is used in patients,... Read more

Imaging IT

view channel

Interactive Dashboard and Visualization Tool Designed for Oncologists

A new tool has been developed to help users of an information system for radiation oncology to analyze data and use metrics to help make more informed decisions. Varian Medical Systems (Palo Alto CA, USA), a developer of cancer treatment technology and informatics software for managing comprehensive cancer clinics, will... Read more

Industry News

view channel

USD 12 Billion Out of Total Spent on Medical Imaging Squandered in the US

The United States wastes close to USD 12 billion on unnecessary medical imaging yearly, according to a new survey of 196 hospital leaders. Smart data company peer60 (American Fork, UT, USA) surveyed 196 healthcare leaders about medical imaging in less than two weeks and found a number of reasons for the squandered resources.... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.