Features | Partner Sites | Information | LinkXpress
Sign In
SCHILLER AG
TERARECON, INC.
AMPRONIX

MRI Study to Offer New Strategies for Chronic Kidney Disease Treatments

By Medimaging International staff writers
Posted on 26 Feb 2014
Detailed structural and functional maps of the human kidney generated using cutting-edge scanning technology are being developed in an effort to optimize treatment strategies for those suffering from chronic kidney disease.

The research, conducted by scientists from the University of Nottingham (UK), is being funded with GBP 107,623 from the Dr. Hadwen Trust, a non-animal biomedical research charity. The goal of the project is to try to further determine of how the kidneys function, ultimately leading to enhanced monitoring, and treatment for chronic kidney disease. It will be the first of its kind to use magnetic resonance imaging (MRI) to study the role oxygen plays in keeping the human kidney healthy.

The study is being led by Dr. Sue Francis at the University’s Sir Peter Mansfield Magnetic Resonance Center in collaboration with Prof. Chris McIntyre at the University’s School of Medicine. Dr. Francis said, “Current tests for chronic kidney disease can be very invasive and patients may need to return to the hospital on a number of occasions. The aim of this project is to produce a set of noninvasive measurements that we can produce in a single, one-hour scanning session that can assess the blood flow and oxygenation of the kidney and which could eventually be rolled out in a clinical setting to benefit patients.”

Disease is now diagnosed by a blood test that measures the glomerular filtration rate (GFR). In more serious kidney disorders, a renal biopsy may need to be performed. Dr. Francis added, “Current methods can only offer a fairly crude picture of what is happening in the kidneys and how that is changing over time. For example, if one kidney is doing most of the work it can be difficult to tell and taking just a small sample of tissue from one area of the kidney may not be representative of the organ as a whole.”

The study will instead use magnetic resonance imaging (MRI), powered by a 3-Tesla magnet, to scan the kidney and construct a comprehensive image of perfusion in the kidney. It will also measure the metabolic rate of oxygen, which has not been done before using MRI technology. The research will employ new MRI technology, and use these techniques in healthy volunteers to study the kidney’s response to oxygen and CO2 changes to evaluate how the kidney acts under stress, which mimics diseased kidneys. Next, the researchers will scan 20 patients with diabetic nephropathy in an effort to validate the effectiveness of their approach. The scanning technique could be used to monitor the progression of a patient’s disease and to monitor the effect and effectiveness of drugs being used to treat the disorder.

Related Links:

University of Nottingham 



RTI ELECTRONICS AB
SuperSonic Imagine
RADCAL

Channels

Ultrasound

view channel
Image: Siemens Healthcare has launched the HELX Evolution, the newest iteration of its Acuson S range of ultrasound imaging systems (Photo courtesy of Siemens Healthcare).

Ultrasound Imaging System Enhancements Include High Definition Transducers, Sophisticated Elastography, and Tissue Strain Analysis

New features designed for a range of ultrasound systems include enhanced image quality with a large 21.5-inch liquid crystal diode (LCD) monitor, high definition (HD) transducers, optimized contrast agent... Read more

Nuclear medicine

view channel
Image: Sagittal section of brain PET image at four hours after 64CuCl2 injection with disulfiram or D-penicillamine in MD model mice (Photo courtesy of the RIKEN Center for Life Science Technologies).

PET Imaging Used to Assess Effectiveness of Menkes Disease Treatments

Japanese scientists are using positron emission tomography (PET) imaging to visualize the distribution of copper in the body using lab mice. Copper distribution is deregulated in a genetic disorder called... Read more

General/Advanced Imaging

view channel

Secondary Light Emission Generated by Plasmonic Nanostructures May Improve Medical Imaging Technology

New clues into light emission at different wavelengths generated by elements known plasmonic nanostructures may help to improve medical imaging technology. A plasmon is a quantum of plasma oscillation. The plasmon is a quasiparticle resulting from the quantization of plasma oscillations just as photons, and phonons are... Read more

Imaging IT

view channel

Software Designed for the Assessment of Orthopedic Implant Fixation and Bone Segment Motion

Model-based roentgen stereophotogrammetric analysis (MBRSA) software has been developed for evaluation of orthopedic implant fixation and bone segment motion. The software is the first to measure the in vivo three-dimensional (3D) position and/or relative motion of metal implants, markers beads, and/or bone segments in... Read more

Industry News

view channel

Collaboration Expands Capacity for Proton Therapy Clinical Research and Patient Treatments

Varian Medical Systems (Palo Alto, CA, USA) and the Paul Scherrer Institute (PSI; Villigen PSI, Switzerland) are extending an existing collaboration in the field of proton therapy to offer patients more accurate cancer treatments using intensity-modulated proton therapy (IMPT). Under the agreement, Varian will also... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.