Image: Magnetic resonance image (MRI) of a beating heart (Photo courtesy of the Berlin Ultrahigh Field Facility / Charité-Universitätsmedizin Berlin).
Images generated in one of the world's most powerful magnetic resonance imaging (MRI) systems provide much higher detail than cardiac images typically generated in current clinical practice.
The ultra-high field application permits a remarkable delineation between blood and heart muscle. Even subtle anatomic structures are made clearly visible. The new technology has the potential to advance the capabilities of cardiac research and care because cardiac malfunctions can be diagnosed, treated, and monitored at a much earlier point in disease progression.
For cardiac imaging in ultrahigh fields new versions of multichannel transmit and receive antennas--so-called radiofrequency coils--were developed at the Berlin Ultrahigh Field Facility (BUFF; Germany) located at Campus Buch. For this purpose a joint collaboration between the Charité-Universitätsmedizin Berlin, the Max Delbrück Center for Molecular Medicine (MDC; Berlin, Germany), the German Metrology Institute (Braunschweig, Germany), and Siemens Healthcare (Erlangen, Germany) was initiated.
To make use of the capacity and traits of the strong magnetic field, a cutting-edge triggering device was developed to synchronize cardiac imaging with heart motion. This approach eliminates mis-synchronization frequently encountered with traditional triggering devices and therefore helps to generate sharp cardiac images, a feature that might be compared with sport macros used in digital photography.
"We correlate the image exposure with the heartbeat," explained the investigator of the study, Prof. Thoralf Niendorf, whose research was published in the March 2011 issue of the Journal for Magnetic Resonance Imaging
. "Our procedure is immune to interference with strong magnetic fields so that we can compensate for the motion of the heart which results in high image quality free of cardiac motion induced blurring and artifacts."
The Berlin-based team, led by Prof. Thoralf Niendorf, Prof. Jeanette Schulz-Menger from the Charité, and Dr. Bernd Ittermann from the German Metrology Institute, used the new technologies to derive for the first time a clearly defined image of the beating heart in a magnetic field with a strength of 7.0 Tesla.
This advancement in technology culminated in images of the beating heart with a spatial resolution that is by far superior to that previously available, and which might come close to turning a 10 megapixel digital camera into a 50 megapixel digital camera. The innovative technology customized for cardiac MRI together with the quality of the anatomic and functional images have created excitement among the international imaging community. The first clinical findings and experiences were very encouraging, according to the researchers, and are the driving force for broader clinical studies.
Berlin Ultrahigh Field Facility
Charité -Universitätsmedizin Berlin