Features | Partner Sites | Information | LinkXpress
My Account
Ampronix
Schiller
ElsMed

TOF PET Images Offer Improved Detection, Safer for Patients

By Medimaging International staff writers
Posted on 16 Mar 2011
For the first time, quantitative--not qualitative--data analysis has demonstrated that time-of-flight (TOF) positron emission tomography (PET) imaging scans can improve cancer detection. Research revealed that oncologic TOF fluorodeoxyglucose (FDG) PET scans yielded considerable improvements in lesion detection of lung and liver cancers over all contrasts and body mass indexes.

Traditional PET scans create images by detecting gamma rays produced by radioisotopes that are injected into the body. Although these conventional scans track where the gamma rays go, they do not gauge the time it takes for each gamma ray to reach the detector. TOF PET scans do take into account the travel time, which results in improved image signal-to-noise.
"[We] …aimed to objectively quantify the improvement in lesion detection that can be achieved with whole-body TOF FDG PET,” said Dr. Joel S. Karp, from the department of radiology, University of Pennsylvania (Philadelphia, USA), and one of the authors of the study, which was published in the March 2011 issue of the Journal of Nuclear Medicine. "In contrast with previously published studies that reported comparison of TOF and non-TOF PET using simulated data or measured data with physical phantoms, this study used whole-body patient data...”

To create a lesion-present-clinical-study while ensuring precise knowledge of the presence and location of each lesion, 10-mm spheric lesions were added to disease-free bed positions, yielding fused lesion-present studies. These studies appropriately corrected for the body's attenuation so that the presence or absence of the lesions was similar to that of actual patient studies. TOF PET scans were performed, and researchers used a numeric observer--as opposed to a human observer--to identify quickly a large number of conditions. The TOF PET images were compared to traditional PET images (the same data reconstructed without TOF information) to determine improvement in lesion detection as a function of lesion location, scan time, contrast and body mass index.

Improved lesion detection was seen in the TOF PET scans, with the greatest gains achieved in the shortest-acquisition studies and in the subjects with a BMI of 30 or more. Also of interest--the greatest gain in performance was achieved at the lowest lesion contrast and the smallest gain in performance at the highest lesion contrast.

Nuclear medicine technologists and physicians may be able to take advantage of the gain achieved with TOF PET to reduce scanning time, therefore increasing patient comfort and minimizing patient motion. They may also be able to reduce the injected radiopharmaceutical dose, thereby reducing the exposure of patients and health professionals to radiation.

Related Links:

University of Pennsylvania





Channels

Radiography

view channel
Image: Bar graph shows the change in detection method over time (1990-2011) for breast cancer cases in patients aged 75 years and older (n = 1162). Pt/PhysD = detection by patient or physician (Photo courtesy of the Radiological Society of North America).

Mammography Screening Helpful for Women Over 75

Mammography-identified breast cancer is associated with a change to earlier-stage diagnosis in older women, which was shown to result in reducing the rate of more advanced, hard-to-treat cases, according... Read more

MRI

view channel
Image: The levels of activity in different parts of the spinal cord of resting individuals were measured using fMRI (Photo courtesy of Barry RL, Smith SA, Dula AN, et al, eLIfe journal, August 5, 2014).

Ultrahigh-Field fMRI Findings May Help Patients Recover from Spinal Cord Injury

Researchers have achieved the first validated noninvasive measurement of neural signaling in the spinal cords of healthy human volunteers. Their imaging technology may aid efforts to help patients recover... Read more

Ultrasound

view channel
Image: Ultrasound image of the Circle of Willis (Photo courtesy of the Swedish Cerebrovascular Center, Seattle, WA, USA).

New Approaches for Transcanial Ultrasound Used for the Treatment of Brain Tumors and Targeted Drug Delivery

A study completed by a Finnish researcher provides new insights into the limitations and potential new directions for the future advancement of transcranial ultrasound therapy. Active research is ongoing... Read more

General/Advanced Imaging

view channel

Diagnostic Imaging Tests Ordered by General Practitioners in Australia Nearly Double in 10 Years

A 45% increase in diagnostic imaging tests ordered by Australian general practitioners (GPs) is being fueled by increasing GP visits, an escalating number of problems managed at doctor visits, and a higher probability that GPs order imaging tests for these problems, according to a new study. Based on a long-term national... Read more

Imaging IT

view channel
Image: An X-ray using the ClearRead bone suppression software technology (Photo courtesy of Riverain Technologies).

Bone Suppression Software Used to Optimize Diagnostic Capability of X-Ray Systems

Clinicians are gathering important information from the most routine imaging exam, the chest X-ray, by using advanced software that enhances X-ray images captured by the equipment they already have or... Read more

Industry News

view channel

Acquisition Includes Radiation Simulation Software for Radiotherapy Applications

Varian Medical Systems, Inc. (Palo Alto, CA, USA) has acquired certain assets of Transpire, Inc. (Gig Harbor, WA, USA) including the Acuros dose calculation software, which has been incorporated into Varian’s BrachyVision and Eclipse treatment planning software systems. The acquisition closed at the end of July 2014.... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.